Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | TACR1 | P25103 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7037557 | 0.88 | HTR1D (0.72) | HTR1D | |
| SCHEMBL8187682 | 0.81 | TRPV6 (0.56) | HTR1DSIGMAR1TACR1MEN1KMT2A | |
| SCHEMBL7038207 | 0.78 | HTR1D (0.69) | HTR1DSIGMAR1MEN1KMT2AALDH1A1 | |
| SCHEMBL9038176 | 0.78 | GAA (0.47) | SIGMAR1MEN1KMT2A | |
| SCHEMBL667793 | 0.76 | ALDH1A1 (0.61) | HTR1DSIGMAR1MEN1KMT2AKDM4E | |
| SCHEMBL9035305 | 0.74 | HTR1D (1.00) | HTR1D | |
| SCHEMBL7107899 | 0.74 | HTR1D (0.54) | HTR1D | |
| SCHEMBL20804357 | 0.73 | SIGMAR1 (0.90) | SIGMAR1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL28186295 | 0.73 | SIGMAR1 (0.90) | SIGMAR1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7038208 | 0.73 | TRPV6 (0.62) | HTR1DSIGMAR1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0546583-B1 | Piperazinyl-and piperidinyl-cyclohexanols | BRISTOL MYERS SQUIBB CO (US) | 1996-05-22 | — | — | EP | claimed |
| EP-0546583-A1 | Piperazinyl-and piperidinyl-cyclohexanols | Bristol-Myers Squibb Company (US) | 1993-06-16 | — | — | EP | claimed |
| EP-1037637-B1 | USE OF 5HT1A RECEPTOR ANTAGONISTS FOR PREVENTING AND/OR TREATING TEMPORAL LOBE EPILEPSY | UNIV PRINCETON (US) | 2003-03-19 | — | — | EP | disclosed |
| EP-1037637-A1 | USE OF 5HT1A RECEPTOR ANTAGONISTS FOR PREVENTING AND/OR TREATING TEMPORAL LOBE EPILEPSY | PRINCETON UNIVERSITY (US) | 2000-09-27 | — | — | EP | disclosed |
| US-5919802-A | Methods of preventing and/or treating temporal lobe epilepsy | PRINCETON UNIVERSITY (US) | 1999-07-06 | — | — | US | disclosed |
| WO-1999029323-A1 | USE OF 5HT1A RECEPTOR ANTAGONISTS FOR PREVENTING AND/OR TREATING TEMPORAL LOBE EPILEPSY | PRINCETON UNIVERSITY (US) | 1999-06-17 | — | — | WO | disclosed |
| EP-0546583-B1 | Piperazinyl-and piperidinyl-cyclohexanols | BRISTOL MYERS SQUIBB CO (US) | 1996-05-22 | — | — | EP | disclosed |
| US-5478828-A | Anxiolytic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-12-26 | — | — | US | disclosed |
| US-5387593-A | Anxiolytic agents | BRISTON-MYERS SQUIBB (US) | 1995-02-07 | — | — | US | disclosed |
| EP-0546583-A1 | Piperazinyl-and piperidinyl-cyclohexanols | Bristol-Myers Squibb Company (US) | 1993-06-16 | — | — | EP | disclosed |