Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ICMT | O60725 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7651322 | 0.98 | NPC1 (0.51) | NPC1JAK2RAB9APAX8TACR1 | |
| SCHEMBL16415141 | 0.98 | NPC1 (0.51) | NPC1JAK2RAB9APAX8TACR1 | |
| SCHEMBL16415177 | 0.98 | NPC1 (0.51) | NPC1JAK2RAB9APAX8TACR1 | |
| SCHEMBL707050 | 0.98 | NPC1 (0.51) | NPC1JAK2RAB9APAX8TACR1 | |
| SCHEMBL3458582 | 0.98 | NPC1 (0.51) | NPC1JAK2RAB9APAX8TACR1 | |
| SCHEMBL1685969 | 0.98 | NPC1 (0.51) | NPC1JAK2RAB9APAX8TACR1 | |
| SCHEMBL16414653 | 0.98 | NPC1 (0.51) | NPC1JAK2RAB9APAX8TACR1 | |
| SCHEMBL489809 | 0.94 | TDP1 (0.46) | NPC1JAK2RAB9APAX8TACR1 | |
| Chloromethane SCHEMBL7281088 | 0.91 | NPC1 (0.44) | NPC1JAK2RAB9APAX8TACR1 | |
| SCHEMBL709444 | 0.86 | TP53 (0.44) | NPC1JAK2RAB9APAX8TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2841433-B1 | TETRAZOLINONE COMPOUNDS AND ITS USE | SUMITOMO CHEMICAL CO (JP) | 2017-06-21 | — | — | EP | disclosed |
| US-9380782-B2 | Tetrazolinone compounds and its use | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2016-07-05 | — | — | US | disclosed |
| US-20150376124-A1 | ANTI-CANCER COMPOSITIONS AND METHODS | PENN STATE RES FOUND (US) | 2015-12-31 | — | — | US | disclosed |
| US-9126911-B2 | Anti-cancer compositions and methods | THE PENN STATE RESEARCH FOUNDATION (US) | 2015-09-08 | — | — | US | disclosed |
| US-9126910-B2 | Anti-cancer compositions and methods | THE PENN STATE RESEARCH FOUNDATION (US) | 2015-09-08 | — | — | US | disclosed |
| US-9096505-B2 | Anti-cancer compositions and methods | THE PENN STATE RESEARCH FOUNDATION (US) | 2015-08-04 | — | — | US | disclosed |
| EP-2841433-A1 | TETRAZOLINONE COMPOUNDS AND ITS USE | Sumitomo Chemical Company Limited (JP) | 2015-03-04 | — | — | EP | disclosed |
| US-20150031733-A1 | TETRAZOLINONE COMPOUNDS AND ITS USE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2015-01-29 | — | — | US | disclosed |
| WO-2013162077-A1 | TETRAZOLINONE COMPOUNDS AND ITS USE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-10-31 | — | — | WO | disclosed |
| US-20130253052-A1 | ANTI-CANCER COMPOSITIONS AND METHODS | THE PENN STATE RESEARCH FOUNDATION (US) | 2013-09-26 | — | — | US | disclosed |
| US-20070167522-A1 | Branched carboxylic acid compound and use thereof | ONO PHARMACEUTICAL CO LTD | 2007-07-19 | — | — | US | disclosed |
| US-20070149595-A1 | Compounds having lysophosphatidic acid receptor antagonism and uses thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-06-28 | — | — | US | disclosed |
| EP-1782830-A1 | PREVENTIVE AND/OR REMEDY FOR LOWER URINARY TRACT DISEASES CONTAINING EP4 AGONIST | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-05-09 | — | — | EP | disclosed |
| EP-1782829-A1 | PREVENTIVE AND/OR REMEDY FOR HYPERKALEMIA CONTAINING EP4 AGONIST | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-05-09 | — | — | EP | disclosed |
| US-20070032529-A1 | Pyrazole compounds and their use as antidiabetes agents | JAPAN TOBACCO INC. (JP) | 2007-02-08 | — | — | US | disclosed |
| EP-1695955-A1 | COMPOUNDS HAVING LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISM AND USES THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-08-30 | — | — | EP | disclosed |
| US-20060148830-A1 | Lpa receptor antagonist | ONO PHARMACEUTICAL CO., LTD. | 2006-07-06 | — | — | US | disclosed |
| US-20060135577-A1 | Remedy for chronic disease | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-06-22 | — | — | US | disclosed |
| EP-1553075-A1 | LPA RECEPTOR ANTAGONISTS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2005-07-13 | — | — | EP | disclosed |
| EP-1550461-A1 | REMEDY FOR CHRONIC DISEASE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2005-07-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150376124-A1 | ANTI-CANCER COMPOSITIONS AND METHODS | MKI67, BAX, BCL2 | NPC1 1407/4885JAK2 325/4885RAB9A 3495/4885 |
| US-20150031733-A1 | TETRAZOLINONE COMPOUNDS AND ITS USE | CBR3, CYP51A1, CYP8B1 | NPC1 2859/4885JAK2 1162/4885RAB9A 515/4885 |
| US-20130253052-A1 | ANTI-CANCER COMPOSITIONS AND METHODS | MKI67, BAX, BCL2 | NPC1 1407/4885JAK2 325/4885RAB9A 3495/4885 |
| US-20070149595-A1 | Compounds having lysophosphatidic acid receptor antagonism and uses thereof | LPAR2, LPAR1, LPAR5 | NPC1 1569/4885JAK2 2437/4885RAB9A 3973/4885 |
| US-20070032529-A1 | Pyrazole compounds and their use as antidiabetes agents | PYGL, GYS2, AGL | NPC1 2838/4885JAK2 1833/4885RAB9A 2748/4885 |
| US-20060135577-A1 | Remedy for chronic disease | EDNRA, EDNRB, LPAR2 | NPC1 1697/4885JAK2 2316/4885RAB9A 3164/4885 |
| US-20070167522-A1 | Branched carboxylic acid compound and use thereof | BDNF, CA1, BACE1 | NPC1 603/4885JAK2 2376/4885RAB9A 414/4885 |
| US-20060148830-A1 | Lpa receptor antagonist | LPAR1, LPAR2, LPAR4 | NPC1 226/4885JAK2 1077/4885RAB9A 3477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.