SCHEMBL7043680

SCHEMBL7043680

COc1cc2cc[nH]c2cc1OC(C)=O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TNFSF11 O14788 1/20 0.51
TUBB4A P04350 1/20 0.48
TUBB P07437 1/20 0.48
TUBA3C P0DPH7 1/20 0.48
TUBA1B P68363 1/20 0.48
TUBA4A P68366 1/20 0.48
TUBB4B P68371 1/20 0.48
TUBB3 Q13509 1/20 0.48
TUBB2A Q13885 1/20 0.48
TUBB8 Q3ZCM7 1/20 0.48
TUBA3E Q6PEY2 1/20 0.48
TUBA1A Q71U36 1/20 0.48
TUBA1C Q9BQE3 1/20 0.48
TUBB6 Q9BUF5 1/20 0.48
TUBB2B Q9BVA1 1/20 0.48
TUBB1 Q9H4B7 1/20 0.48
TLR8 Q9NR97 1/20 0.48
TLR7 Q9NYK1 1/20 0.48
TSHR P16473 1/20 0.46
MEN1 O00255 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1701759 0.94 CA12 (0.46) TNFSF11TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL1748737 0.85 TLR8 (0.60) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL9736443 0.84 KDM4E (0.40) TNFSF11TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL19186866 0.84 S1PR1 (0.44) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL9735764 0.84 KDM4E (0.40) TNFSF11TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL6717966 0.84 TYR (0.60) MEN1POLBMAPK1KMT2ACA12
SCHEMBL9413340 0.83 ACHE (0.47) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL9442085 0.83 BACE1 (0.42) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL1702125 0.83 BACE1 (0.42) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL23417682 0.82 CA12 (0.38) TNFSF11TUBB4ATUBBTUBA3CTUBA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0597022-B2 PROCESS FOR THE TEMPORARY DYEING OF KERATIN FIBRES INVOLVING AN INSOLUBLE PIGMENT OBTAINED BY THE OXIDATIVE POLYMERISATION OF INDOLE DERIVATIVES OREAL (FR) 1999-11-17 EP claimed
US-5874091-A PROTECTION OF SKIN AND HAIR AGAINST ULTRAVIOLET RADIATION AND FOR PIGMENTATION OF THE SKIN AND HAIR; HOMOGENEOUS AQUEOUS DISPERSION OF LAMELLAR AND ENCAPSULATING VESICLES; STORAGE STABILITY; STORING MELANIN PIGMENT IN THE STRATUM CORNEUM. L'OREAL (FR) 1999-02-23 US claimed
EP-0587837-B1 Cosmetic composition containing melanistic pigments in association with certain tocopherols, and method for protecting the skin, the hair, the mucous membranes and cosmetic compositions OREAL (FR) 1998-06-03 EP claimed
EP-0544874-B1 METHOD FOR PREPARING SUBMICRON PARTICLES IN THE PRESENCE OF LIPID VESICLES, AND CORRESPONDING COMPOSITIONS OREAL (FR) 1998-04-08 EP claimed
US-5695747-A APPLYING TO THE SKIN OR HAIR AND ULTRAVIOLET PROETECTION AGENT L'OREAL (FR) 1997-12-09 US claimed
US-5670099-A PREPARING A DISPERSION OF LIPIDIC VESICLES FROM ATLEAST ONE LIPID, AN AQUEOUS PHASE ENCAPSULATED IN VESICLE, DISSOLVING POLYMERIZABLE INDOLIC OR INDOLINIC MONOMER WITH A POLYMERIZATION AGENT, REACTS WITH MONOMER FORMS PARTICLES L'OREAL (FR) 1997-09-23 US claimed
US-5645609-A Compositions which contain and processes which use an insoluble pigment obtained by the oxidative polymerization of indole derivatives for the temporary dyeing of keratinous fibers L'OREAL (FR) 1997-07-08 US claimed
EP-0575603-B1 PRODUCT BASED ON COLOURED MINERAL PARTICLES INCLUDING A MELANIC PIGMENT, PROCESS FOR PREPARING SAME AND APPLICATION IN COSMETICS OREAL (FR) 1996-10-23 EP claimed
US-5547658-A Cosmetic composition containing melaninlike pigments in combination with certain tocopherols, and process for protecting the skin, hair, mucosae and cosmetic compositions L'OREAL (FR) 1996-08-20 US claimed
EP-0597022-B1 PROCESS FOR THE TEMPORARY DYEING OF KERATIN FIBRES INVOLVING AN INSOLUBLE PIGMENT OBTAINED BY THE OXIDATIVE POLYMERISATION OF INDOLE DERIVATIVES OREAL (FR) 1996-04-03 EP claimed
WO-1993005754-A1 FINE DISPERSION OF MELANIC PIGMENTS, ITS PREPARATION AND UTILISATION IN COSMETICS L'OREAL (FR) 1993-04-01 WO claimed
WO-1993002655-A1 PROCESS FOR THE TEMPORARY DYEING OF KERATIN FIBRES INVOLVING AN INSOLUBLE PIGMENT OBTAINED BY THE OXIDATIVE POLYMERISATION OF INDOLE DERIVATIVES L'OREAL (FR) 1993-02-18 WO claimed
WO-1993000068-A1 METHOD FOR PREPARING SUBMICRON PARTICLES IN THE PRESENCE OF LIPID VESICLES, AND CORRESPONDING COMPOSITIONS L'OREAL (FR) 1993-01-07 WO claimed
EP-0518773-A1 Cosmetic composition containing a blend of metallic oxids nanopigments and melanic pigments L'OREAL (FR) 1992-12-16 EP claimed
EP-0504347-A1 COSMETIC COMPOSITION COMPRISING A DISPERSION OF LIPIDIC VESICLES AS WELL AS MELANIC PIGMENTS. OREAL (FR) 1992-09-23 EP claimed
EP-0496653-A1 Use of indol derivatives as coupling agents in dyeing of keratin fibres L'OREAL (FR) 1992-07-29 EP claimed
US-5126125-A Decreasing the melanin content in mammalian skin and hair using 5,6-dihydroxindole derivatives YALE UNIVERSITY (US) 1992-06-30 US claimed
WO-1992005761-A1 COSMETIC COMPOSITION COMPRISING A DISPERSION OF LIPIDIC VESICLES AS WELL AS MELANIC PIGMENTS L'OREAL (FR) 1992-04-16 WO claimed
EP-0467767-A1 Product based on flaky particles containing melanine pigment and process for their preparation L'OREAL (FR) 1992-01-22 EP claimed
US-4822375-A LIGHTFAST, WEATHER RESISTANT, NATURAL APPEARING HAIR DYES L'OREAL (FR) 1989-04-18 US claimed