SCHEMBL704466

SCHEMBL704466

CCCCCCC([SiH3])(OC(C)(C)C)c1cccc2c1Cc1ccccc1-2

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PNMT P11086 1/20 0.36
CNR1 P21554 4/20 0.33
CNR2 P34972 4/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
HSP90AA1 P07900 1/20 0.32
HSP90AB1 P08238 1/20 0.32
HTR7 P34969 1/20 0.31
HTR2B P41595 1/20 0.31
ALDH1A1 P00352 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C19 P33261 1/20 0.31
LMNA P02545 1/20 0.30
GAA P10253 1/20 0.30
SIGMAR1 Q99720 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8060281 0.77 PNMT (0.41) PNMTCNR1CNR2NPC1RAB9A
SCHEMBL29111158 0.76 PNMT (0.40) PNMTCNR1CNR2NPC1RAB9A
SCHEMBL3786405 0.74 PNMT (0.38) PNMTCNR1CNR2NPC1RAB9A
SCHEMBL1448599 0.73 PNMT (0.42) PNMTNPC1RAB9AHSP90AA1HSP90AB1
SCHEMBL5837265 0.70 PNMT (0.49) PNMTNPC1RAB9AHTR7HTR2B
SCHEMBL2043313 0.70 PNMT (0.49) PNMTNPC1RAB9AHTR7HTR2B
Fluorene SCHEMBL27803639 0.69 ALDH1A1 (0.50) PNMTNPC1RAB9AALDH1A1CYP1A2
Fluorene SCHEMBL28135016 0.69 ALDH1A1 (0.50) PNMTNPC1RAB9AALDH1A1CYP1A2
SCHEMBL28124467 0.69 S1PR5 (0.48) PNMTHTR2BCYP1A2CYP2C19LMNA
SCHEMBL27661475 0.68 PNMT (0.35) PNMTNPC1RAB9AALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1784431-B1 SUPPORTED METALLOCENE CATALYST, METHOD OF PREPARING THE CATALYST AND METHOD OF PREPARING POLYOLEFIN USING THE CATALYST LG CHEMICAL LTD (KR) 2015-01-07 EP disclosed
US-8124557-B2 Supported metallocene catalyst, method of preparing the catalyst and method of preparing polyolefin using the catalyst LG CHEM, LTD. (KR) 2012-02-28 US disclosed
EP-1784431-A1 SUPPORTED METALLOCENE CATALYST, METHOD OF PREPARING THE CATALYST AND METHOD OF PREPARING POLYOLEFIN USING THE CATALYST LG Chem. Ltd. (KR) 2007-05-16 EP disclosed
WO-2006025709-A1 SUPPORTED METALLOCENE CATALYST, METHOD OF PREPARING THE CATALYST AND METHOD OF PREPARING POLYOLEFIN USING THE CATALYST LG CHEM. LTD. (KR) 2006-03-09 WO disclosed
US-20060052238-A1 Supported metallocene catalyst, method of preparing the catalyst and method of preparing polyolefin using the catalyst LG CHEM. LTD. (KR) 2006-03-09 US disclosed