Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CCKBR | P32239 | 1/20 | 0.41 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635136 | 0.91 | NPC1 (0.52) | HPGDOPRK1PDE4DHTR7HTR1A | |
| SCHEMBL8083936 | 0.87 | LMNA (0.46) | HTR7HTR1ADRD2DRD5DRD3 | |
| SCHEMBL11754667 | 0.85 | OPRK1 (0.70) | HPGDOPRK1PDE4DHTR1ADRD2 | |
| SCHEMBL8616366 | 0.84 | CCKBR (0.51) | HPGDOPRK1PDE4DHTR7HTR1A | |
| SCHEMBL8616731 | 0.84 | CCKBR (0.51) | HPGDOPRK1PDE4DHTR7HTR1A | |
| SCHEMBL8639633 | 0.84 | KMT2A (0.62) | HPGDOPRK1PDE4DHTR7HTR1A | |
| SCHEMBL9603352 | 0.82 | CCKBR (0.49) | HPGDOPRK1PDE4DHTR7HTR1A | |
| SCHEMBL4422153 | 0.82 | HPGD (0.74) | HPGDOPRK1PDE4DMAPTMEN1 | |
| SCHEMBL11557377 | 0.81 | OPRL1 (0.43) | OPRK1PDE4DHTR7HTR1ADRD2 | |
| SCHEMBL30087538 | 0.79 | OPRK1 (0.70) | HPGDOPRK1PDE4DMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842156-B1 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO INC (US) | 2003-04-09 | — | — | EP | disclosed |
| EP-0842156-A4 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO INC (US) | 1998-11-11 | — | — | EP | disclosed |
| EP-0842156-A1 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | Merck & Co., Inc. (US) | 1998-05-20 | — | — | EP | disclosed |
| US-5700797-A | N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides | MERCK & CO, INC. (US) | 1997-12-23 | — | — | US | disclosed |
| WO-1996040654-A1 | NOVEL N-(2,4-DIOXO-2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPIN-3YL)-3-AMIDES | MERCK & CO., INC. (US) | 1996-12-19 | — | — | WO | disclosed |