SCHEMBL8635136

SCHEMBL8635136

CCCCN1C(=O)CC(=O)N(c2ccccc2)c2ccccc21

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.52
RAB9A P51151 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
HPGD P15428 3/20 0.50
CCKBR P32239 1/20 0.50
DRD2 P14416 3/20 0.47
DRD3 P35462 3/20 0.47
CHRM2 P08172 2/20 0.47
CHRM4 P08173 2/20 0.47
CHRM5 P08912 2/20 0.47
CHRM1 P11229 2/20 0.47
CHRM3 P20309 2/20 0.47
DRD4 P21917 2/20 0.47
HTR7 P34969 2/20 0.46
HTR1A P08908 1/20 0.46
DRD5 P21918 1/20 0.46
OPRK1 P41145 1/20 0.46
PDE4D Q08499 1/20 0.46
MAPT P10636 4/20 0.41
ALDH1A1 P00352 3/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7044712 0.91 HPGD (0.53) NPC1RAB9ASMN1; SMN2HPGDCCKBR
SCHEMBL11761654 0.86 OPRK1 (0.67) NPC1RAB9ASMN1; SMN2HPGDCCKBR
SCHEMBL5451996 0.85 NPC1 (0.55) NPC1RAB9ASMN1; SMN2HPGDCCKBR
SCHEMBL10797889 0.83 NPC1 (0.68) NPC1RAB9ASMN1; SMN2HPGDCCKBR
SCHEMBL11552779 0.82 DRD2 (0.51) NPC1RAB9ASMN1; SMN2DRD2DRD3
SCHEMBL8616731 0.82 CCKBR (0.51) HPGDCCKBRDRD2DRD3HTR7
SCHEMBL8616366 0.82 CCKBR (0.51) HPGDCCKBRDRD2DRD3HTR7
SCHEMBL8639633 0.81 KMT2A (0.62) RAB9ASMN1; SMN2HPGDCCKBRDRD2
SCHEMBL5145641 0.80 MAPT (0.55) NPC1RAB9ASMN1; SMN2HPGDHTR7
SCHEMBL9603352 0.80 CCKBR (0.49) HPGDCCKBRDRD2DRD3HTR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4001408-A SUBSTITUTED HETEROCYCLIC COMPOUNDS, PROCESSES AND COMPOSITION INCLUDING THOSE ROUSSEL-UCLAF (FR) 1977-01-04 US claimed
US-3984398-A 1,5-Benzodiazepine-2,4-diones ROUSSEL-UCLAF (FR) 1976-10-05 US claimed
EP-0558104-B1 1,5-Benzodiazepine derivatives and their use in medicine GLAXO WELLCOME SPA (IT) 1998-07-29 EP disclosed
EP-0853764-A1 COMBINATORIAL SYNTHESIS AND HIGH-THROUGHPUT SCREENING OF A REV-INHIBITING ARYLIDENEDIAMIDE ARRAY ARQULE, INC. (US) 1998-07-22 EP disclosed
US-5637697-A ANTAGONIST TO GASTRIN AND(OR) CHLOROCYSTOKININ GLAXO SPA (IT) 1997-06-10 US disclosed
US-5580895-A GASTROINTESTINAL OR CENTRAL NERVOUS SYSTEM DISORDERS GLAXO SPA (IT) 1996-12-03 US disclosed
WO-1996035953-A1 COMBINATORIAL SYNTHESIS AND HIGH-THROUGHPUT SCREENING OF A REV-INHIBITING ARYLIDENEDIAMIDE ARRAY ARQULE, INC. (US) 1996-11-14 WO disclosed
EP-0558104-A1 1,5-Benzodiazepine derivatives and their use in medicine GLAXO S.p.A. (IT) 1993-09-01 EP disclosed
US-4138572-A Malonanilic derivatives ROUSSEL UCLAF (FR) 1979-02-06 US disclosed
US-4001408-A SUBSTITUTED HETEROCYCLIC COMPOUNDS, PROCESSES AND COMPOSITION INCLUDING THOSE ROUSSEL-UCLAF (FR) 1977-01-04 US disclosed
US-3984398-A 1,5-Benzodiazepine-2,4-diones ROUSSEL-UCLAF (FR) 1976-10-05 US disclosed