Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.65 |
| ▸ | F10 | P00742 | 9/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5698749 | 0.85 | PTGS2 (0.80) | PTGS2PTGS1F10GRIA2CYP1A2 | |
| SCHEMBL7041609 | 0.80 | PTGS1 (0.62) | PTGS2PTGS1 | |
| SCHEMBL5698714 | 0.79 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL7222935 | 0.74 | PTGS1 (0.55) | PTGS2PTGS1GRIA2CYP1A2CYP2D6 | |
| SCHEMBL8989445 | 0.72 | PTGS2 (0.70) | PTGS2PTGS1F10MAPTKDM4E | |
| SCHEMBL8039330 | 0.72 | PTGS2 (0.68) | PTGS2PTGS1F10 | |
| SCHEMBL6167942 | 0.67 | PTGS2 (0.66) | PTGS2PTGS1 | |
| SCHEMBL6339161 | 0.67 | PTGS2 (0.74) | PTGS2PTGS1 | |
| SCHEMBL6390454 | 0.67 | PTGS2 (0.38) | PTGS2PTGS1GRIA2MAPTALDH1A1 | |
| SCHEMBL6168379 | 0.67 | PTGS2 (0.65) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030236258-A1 | Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents | PFIZER INC. | 2003-12-25 | — | — | US | disclosed |
| US-6538009-B2 | Selective cyclooxygenase-2 (COX-2) inhibitors; for example, 1-(5-Methanesulfonyl-pyridin-2-yl)-7-methoxy-3-trifluoromethyl-4,5-dihydro -1H-benzo(g) indazole | PFIZER, INC. | 2003-03-25 | — | — | US | disclosed |
| US-6531492-B1 | Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents | PFIZER INC. | 2003-03-11 | — | — | US | disclosed |
| EP-1233959-A1 | HETEROCYCLO-ALKYLSULFONYL PYRAZOLE DERIVATIVES AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | Pfizer Products Inc. (US) | 2002-08-28 | — | — | EP | disclosed |
| US-20020115856-A1 | Pyrazole derivatives as anti-inflammatory/analgesic agents | SAKYA SUBAS MAN (US) | 2002-08-22 | — | — | US | disclosed |
| EP-1142889-A1 | Pyrazole derivatives as anti-inflammatory/analgesic agents | Pfizer Products Inc. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2001040216-A1 | HETEROCYCLO-ALKYLSULFONYL PYRAZOLE DERIVATIVES AS ANTI-INFLAMMATORY/ANALGESIC AGENTS | PFIZER PRODUCTS INC. (US) | 2001-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030236258-A1 | Heterocyclo-alkylsulfonyl pyrazole derivatives as anti-inflammatory/analgesic agents | PTGS1, SULT2A1, PTGES3 | PTGS2 4/4885PTGS1 1/4885F10 1821/4885 |
| US-20020115856-A1 | Pyrazole derivatives as anti-inflammatory/analgesic agents | FPR3, P2RX3, FPR1 | PTGS2 72/4885PTGS1 27/4885F10 502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.