Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Tyramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.78 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.78 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.47 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.47 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 7/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.78 |
| ▸ | HTR1A | P08908 | 2/20 | 0.78 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.78 |
| ▸ | HTR3A | P46098 | 1/20 | 0.78 |
| ▸ | BACE1 | P56817 | 1/20 | 0.78 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.78 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.75 |
| ▸ | BLM | P54132 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.75 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyramine SCHEMBL236651 | 1.00 | TAAR1 (0.78) | TAAR1KDM4EALDH1A1HTR1AADRA2A | |
| Tyramine SCHEMBL4111 | 0.89 | TAAR1 (1.00) | TAAR1KDM4EALDH1A1HTR1AADRA2A | |
| Tyramine SCHEMBL134515 | 0.89 | TAAR1 (1.00) | TAAR1KDM4EALDH1A1HTR1AADRA2A | |
| Tyramine SCHEMBL30831107 | 0.89 | TAAR1 (1.00) | TAAR1KDM4EALDH1A1HTR1AADRA2A | |
| Tyramine SCHEMBL30831130 | 0.89 | TAAR1 (1.00) | TAAR1KDM4EALDH1A1HTR1AADRA2A | |
| Tyramine SCHEMBL7742928 | 0.86 | TAAR1 (0.95) | TAAR1KDM4EALDH1A1HTR1AADRA2A | |
| Tyramine SCHEMBL2121 | 0.86 | TDP1 (1.00) | TAAR1KDM4EALDH1A1HTR1AADRA2A | |
| Tyramine SCHEMBL1804993 | 0.86 | TAAR1 (0.95) | TAAR1KDM4EALDH1A1HTR1AADRA2A | |
| Tyramine SCHEMBL31718804 | 0.86 | TAAR1 (0.95) | TAAR1KDM4EALDH1A1HTR1AADRA2A | |
| Tyramine SCHEMBL3950268 | 0.86 | TAAR1 (0.95) | TAAR1KDM4EALDH1A1HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144199-B1 | PRINTING PLATES AND A METHOD FOR THEIR PREPARATION | EASTMAN KODAK CO (US) | 2003-03-26 | — | — | EP | disclosed |
| US-6520086-B1 | Printing plates and a method for their preparation | EASTMAN KODAK COMPANY | 2003-02-18 | — | — | US | disclosed |
| EP-1144199-A2 | PRINTING PLATES AND A METHOD FOR THEIR PREPARATION | EASTMAN KODAK COMPANY (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000037261-A2 | PRINTING PLATES AND A METHOD FOR THEIR PREPARATION | EASTMAN KODAK COMPANY (US) | 2000-06-29 | — | — | WO | disclosed |