Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Tyramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 0.95 |
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.95 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.95 |
| ▸ | HTR3A known ✓ | P46098 | 1/20 | 0.95 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.65 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.65 |
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.58 |
| ▸ | DRD1 known ✓ | P21728 | 2/20 | 0.58 |
| ▸ | DRD4 known ✓ | P21917 | 2/20 | 0.58 |
| ▸ | DRD3 known ✓ | P35462 | 2/20 | 0.58 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.58 |
| ▸ | GAA known ✓ | P10253 | 1/20 | 0.58 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.56 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.54 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.54 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.54 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.54 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.54 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.54 |
| ▸ | MAOB known ✓ | P27338 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyramine SCHEMBL32663617 | 1.00 | TDP1 (1.00) | TDP1BLMKMT2ATAAR1KDM4E | |
| Tyramine SCHEMBL134515 | 0.97 | TAAR1 (1.00) | TDP1BLMKMT2ATAAR1KDM4E | |
| Tyramine SCHEMBL30831107 | 0.97 | TAAR1 (1.00) | TDP1BLMKMT2ATAAR1KDM4E | |
| Tyramine SCHEMBL30831130 | 0.97 | TAAR1 (1.00) | TDP1BLMKMT2ATAAR1KDM4E | |
| Tyramine SCHEMBL4111 | 0.97 | TAAR1 (1.00) | TDP1BLMKMT2ATAAR1KDM4E | |
| Tyramine SCHEMBL31738431 | 0.95 | TAAR1 (0.95) | TDP1BLMKMT2ATAAR1KDM4E | |
| Tyramine SCHEMBL3950268 | 0.95 | TAAR1 (0.95) | TDP1BLMKMT2ATAAR1KDM4E | |
| Tyramine SCHEMBL2574990 | 0.95 | TAAR1 (0.95) | TDP1BLMKMT2ATAAR1KDM4E | |
| Tyramine SCHEMBL31718804 | 0.95 | TAAR1 (0.95) | TDP1BLMKMT2ATAAR1KDM4E | |
| Tyramine SCHEMBL1804993 | 0.95 | TAAR1 (0.95) | TDP1BLMKMT2ATAAR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 937 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122054801-A | Solar cell, preparation method thereof, photovoltaic module, power utilization device and power generation device | 宁德时代新能源科技股份有限公司 | 2026-05-15 | — | — | CN | claimed |
| US-20260125735-A1 | METHOD OF DETECTING TARGET SUBSTANCE AND REAGENT FOR INSPECTION OF TARGET SUBSTANCE | CANON KK (JP) | 2026-05-07 | — | — | US | claimed |
| US-20260126443-A1 | METHOD OF DETECTING TARGET SUBSTANCE AND REAGENT FOR INSPECTION OF TARGET SUBSTANCE | CANON KK (JP) | 2026-05-07 | — | — | US | claimed |
| EP-4737586-A1 | METHOD OF DETECTING TARGET SUBSTANCE AND REAGENT FOR INSPECTION OF TARGET SUBSTANCE | Canon Kabushiki Kaisha (JP) | 2026-05-06 | — | — | EP | claimed |
| EP-4737585-A1 | METHOD OF DETECTING TARGET SUBSTANCE AND REAGENT FOR INSPECTION OF TARGET SUBSTANCE | Canon Kabushiki Kaisha (JP) | 2026-05-06 | — | — | EP | claimed |
| US-12403216-B2 | Chemical modification of silk fibroin for fabrication of enzymatically crosslinked hydrogels with tunable gelation kinetics and bioactivity | TRUSTEES OF TUFTS COLLEGE (US) | 2025-09-02 | — | — | US | claimed |
| CN-120118335-A | Vascular intima repair promoting high-adhesion enzymatic hydrogel and preparation method thereof | 西南交通大学 | 2025-06-10 | — | — | CN | claimed |
| CN-119552384-A | Injectable hydrogel based on gamma-polyglutamic acid and preparation method thereof | 吉林大学 | 2025-03-04 | — | — | CN | claimed |
| CN-119465653-A | Antistatic and antibacterial polyester fabric and preparation method and application thereof | 扬州纪元纺织有限公司 | 2025-02-18 | — | — | CN | claimed |
| CN-114551733-B | 3D/2D tin-lead perovskite solar cell based on tyramine hydrochloride and preparation method thereof | 吉林大学 | 2025-01-21 | — | — | CN | claimed |
| US-20110224335-A1 | INK COMPOSITION AND METHOD OF FABRICATING LIQUID CRYSTAL DISPLAY DEVICE USING THE SAME | KIM SUNG-HEE | 2011-09-15 | — | — | US | claimed |
| US-7935552-B2 | Ink composition and method of fabricating liquid crystal display device using the same | LG DISPLAY CO., LTD. (KR) | 2011-05-03 | — | — | US | claimed |
| US-20100120181-A1 | INK COMPOSITION AND METHOD OF FABRICATING LIQUID CRYSTAL DISPLAY DEVICE USING THE SAME | LG DISPLAY CO., LTD. (KR) | 2010-05-13 | — | — | US | claimed |
| EP-0582441-A1 | Processes for the preparation of tyramine derivatives | CHEMAGIS LTD. (IL) | 1994-02-09 | — | — | EP | claimed |
| EP-0564212-A2 | Process for the preparation of arylethylamines and substituted arylethylamines | HOECHST CELANESE CORPORATION (US) | 1993-10-06 | — | — | EP | claimed |
| EP-0564213-A2 | Process for the preparation of arylethylamines and substituted arylethylamines | HOECHST CELANESE CORPORATION (US) | 1993-10-06 | — | — | EP | claimed |
| US-5220066-A | Process for the preparation of arylethylamines and substituted arylethylamines | HOECHST CELANESE CORPORATION (US) | 1993-06-15 | — | — | US | claimed |
| US-5220067-A | Process for the preparation of arylethylamines and substituted arylethylamines | HOECHST CELANESE CORPORATION (US) | 1993-06-15 | — | — | US | claimed |
| US-5175368-A | Hydrogenating aryl alpha-oximinoalkyl ketones in aqueous medium containing hydrochlroic acid, recovering salt | HOECHST CELANESE CORPORATION (US) | 1992-12-29 | — | — | US | claimed |
| EP-0491557-A1 | Process for the preparation of arylalkylamines and substituted arylalkylamines | HOECHST CELANESE CORPORATION (US) | 1992-06-24 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260126443-A1 | METHOD OF DETECTING TARGET SUBSTANCE AND REAGENT FOR INSPECTION OF TARGET SUBSTANCE | TYR, UCHL1, TH | ADRA2A 3867/4885SLC6A2 1484/4885HTR1A 2396/4885 |
| US-20260125735-A1 | METHOD OF DETECTING TARGET SUBSTANCE AND REAGENT FOR INSPECTION OF TARGET SUBSTANCE | UCHL1, MAOA, ACHE | ADRA2A 2181/4885SLC6A2 1497/4885HTR1A 833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.