Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 13/20 | 0.69 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.65 |
| ▸ | EIF4E | P06730 | 1/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KIF20B | Q96Q89 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7046611 | 0.90 | PARP1 (0.75) | PARP1PARP2EIF4EMAPTKIF20B | |
| SCHEMBL7044881 | 0.88 | PARP1 (0.55) | PARP1PARP2EIF4EMKNK1MKNK2 | |
| SCHEMBL424209 | 0.86 | PARP1 (0.81) | PARP1PARP2 | |
| SCHEMBL31602072 | 0.86 | PARP1 (0.81) | PARP1PARP2 | |
| SCHEMBL7046986 | 0.84 | PARP1 (0.70) | PARP1PARP2 | |
| SCHEMBL7112515 | 0.82 | PARP1 (1.00) | PARP1PARP2 | |
| SCHEMBL7111338 | 0.81 | PARP1 (0.80) | PARP1PARP2 | |
| SCHEMBL7113559 | 0.81 | PARP1 (0.67) | PARP1PARP2AURKARPS6KB1 | |
| SCHEMBL7045309 | 0.81 | PARP1 (0.78) | PARP1PARP2AURKARPS6KB1 | |
| SCHEMBL7042977 | 0.81 | PARP1 (0.78) | PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003007959-A1 | QUINOXALINE DERIVATIVES WHICH HAVE PARP INHIBITORY ACTION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-01-30 | — | — | WO | claimed |
| WO-2003007959-A1 | QUINOXALINE DERIVATIVES WHICH HAVE PARP INHIBITORY ACTION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-01-30 | — | — | WO | disclosed |