Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 14/20 | 0.81 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.73 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.42 |
| ▸ | CBFB | Q13951 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31602072 | 1.00 | PARP1 (0.81) | PARP1PARP2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29709959 | 0.89 | PARP1 (1.00) | PARP1PARP2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL872126 | 0.89 | PARP1 (1.00) | PARP1PARP2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7112515 | 0.88 | PARP1 (1.00) | PARP1PARP2NPC1RAB9ADHODH | |
| SCHEMBL7111338 | 0.87 | PARP1 (0.80) | PARP1PARP2ALDH1A1DHODH | |
| SCHEMBL7042977 | 0.86 | PARP1 (0.78) | PARP1PARP2CASP1KMT2ADHODH | |
| SCHEMBL7045309 | 0.86 | PARP1 (0.78) | PARP1PARP2MAP4K4ATRKDM4E | |
| SCHEMBL7045348 | 0.86 | PARP1 (0.69) | PARP1PARP2 | |
| SCHEMBL7108289 | 0.84 | PARP1 (1.00) | PARP1PARP2CASP1ATR | |
| SCHEMBL4777457 | 0.84 | PARP1 (0.58) | PARP1PARP2NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120022026-A1 | METHOD OF TREATING CANCER | ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM (NL) | 2012-01-26 | — | — | US | claimed |
| EP-2387403-A1 | METHOD OF TREATING CANCER | Academisch Medisch Centrum bij de Universiteit van Amsterdam (NL) | 2011-11-23 | — | — | EP | claimed |
| US-20110253692-A1 | Electrical heater for vehicle windshields and windows | SCHAUBLE RICHARD EGON | 2011-10-20 | — | — | US | claimed |
| WO-2010082821-A1 | METHOD OF TREATING CANCER | ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) | 2010-07-22 | — | — | WO | claimed |
| WO-2010082813-A1 | METHOD OF TREATING CANCER | ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) | 2010-07-22 | — | — | WO | claimed |
| US-12186317-B2 | Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase | TES PHARMA S.R.L. (IT) | 2025-01-07 | — | — | US | disclosed |
| US-20240366568-A1 | COMPOSITIONS AND METHODS FOR TREATING TISSUE INJURY | UNIV CASE WESTERN RESERVE (US) | 2024-11-07 | — | — | US | disclosed |
| CN-118496217-A | Inhibitors of alpha-amino-beta-carboxyhexadienoic acid semialdehyde decarboxylase | TES制药有限责任公司 | 2024-08-16 | — | — | CN | disclosed |
| US-20240105279-A1 | METHODS AND SYSTEMS EMPLOYING TARGETED NEXT GENERATION SEQUENCING FOR CLASSIFYING A TUMOR SAMPLE AS HAVING A LEVEL OF HOMOLOGOUS RECOMBINATION DEFICIENCY SIMILAR TO THAT ASSOCIATED WITH MUTATIONS IN BRCA1 OR BRCA2 GENES | Genomic Testing Cooperative, LCA (US) | 2024-03-28 | — | — | US | disclosed |
| US-11931339-B2 | Compositions and methods for treating tissue injury | CASE WESTERN RESERVE UNIVERSITY (US) | 2024-03-19 | — | — | US | disclosed |
| EP-3419632-B1 | NR OR NMN FOR ENHANCING LIVER REGENERATION | UNIV PENNSYLVANIA (US) | 2023-12-20 | — | — | EP | disclosed |
| US-20230381177-A1 | INHIBITORS OF ALPHA-AMINO-BETA-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE | TES PHARMA S.R.L. (IT) | 2023-11-30 | — | — | US | disclosed |
| WO-2010082821-A1 | METHOD OF TREATING CANCER | ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) | 2010-07-22 | — | — | WO | disclosed |
| WO-2010082813-A1 | METHOD OF TREATING CANCER | ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM (NL) | 2010-07-22 | — | — | WO | disclosed |
| EP-2059802-A2 | METHODS FOR DESIGNING PARP INHIBITORS AND USES THEREOF | Bipar Sciences, Inc. (US) | 2009-05-20 | — | — | EP | disclosed |
| US-20080076778-A1 | METHODS FOR DESIGNING PARP INHIBITORS AND USES THEREOF | BIPAR SCIENCES, INC. (US) | 2008-03-27 | — | — | US | disclosed |
| WO-2008030887-A2 | METHODS FOR DESIGNING PARP INHIBITORS AND USES THEREOF | BIPAR SCIENCES, INC. (US) | 2008-03-13 | — | — | WO | disclosed |
| WO-2008015429-A2 | PHARMACEUTICAL COMPOUNDS | SENTINEL ONCOLOGY LIMITED (GB) | 2008-02-07 | — | — | WO | disclosed |
| WO-2008015429-A2 | PHARMACEUTICAL COMPOUNDS | SENTINEL ONCOLOGY LIMITED (GB) | 2008-02-07 | — | — | WO | disclosed |
| WO-2003007959-A1 | QUINOXALINE DERIVATIVES WHICH HAVE PARP INHIBITORY ACTION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-01-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076778-A1 | METHODS FOR DESIGNING PARP INHIBITORS AND USES THEREOF | PARP3, PARP1, PARP15 | PARP1 2/4885PARP2 9/4885NPC1 3612/4885 |
| US-12186317-B2 | Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase | ACMSD, GLS, ALDH7A1 | PARP1 1532/4885PARP2 2557/4885NPC1 2123/4885 |
| US-11931339-B2 | Compositions and methods for treating tissue injury | PDK4, AK1, PDK1 | PARP1 725/4885PARP2 1209/4885NPC1 4502/4885 |
| US-20230381177-A1 | INHIBITORS OF ALPHA-AMINO-BETA-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE | ACMSD, GLS, ALDH7A1 | PARP1 1532/4885PARP2 2557/4885NPC1 2123/4885 |
| US-20240366568-A1 | COMPOSITIONS AND METHODS FOR TREATING TISSUE INJURY | PDK4, AK1, PDK1 | PARP1 725/4885PARP2 1209/4885NPC1 4502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.