Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | STAT1 | P42224 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8089595 | 0.83 | MAPT (0.46) | MAPTTP53RAB9AMEN1KMT2A | |
| SCHEMBL7046244 | 0.72 | CCR2 (0.40) | MAPTRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL8093064 | 0.67 | PTK2 (0.47) | MAPTRAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8089467 | 0.62 | MAPT (0.41) | MAPTTP53SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL8095087 | 0.62 | RNASEH1 (0.42) | MAPTTP53RAB9AMEN1KMT2A | |
| SCHEMBL7638188 | 0.61 | ALDH1A1 (0.67) | MAPTRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL7463688 | 0.60 | TUBB4A (0.46) | MAPTTP53RAB9AMEN1KMT2A | |
| SCHEMBL2469143 | 0.60 | SMN1; SMN2 (0.52) | MAPTTP53RAB9AMEN1KMT2A | |
| SCHEMBL7641215 | 0.60 | NPSR1 (0.49) | RAB9AMEN1KMT2ANPC1NPSR1 | |
| SCHEMBL13505598 | 0.59 | KMT2A (0.53) | MAPTRAB9AMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054667-A1 | BICYCLIC PYRROLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTIINFLAMMATORY AND IMMUNOMODULATING AGENTS | AstraZeneca UK Limited (GB) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999040913-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA UK LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |