Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL702720 | 0.90 | ALDH1A1 (0.53) | ALDH1A1TSHRFDPSSMN1; SMN2LMNA | |
| 3,4-Dimethoxybenzaldehyde SCHEMBL2529644 | 0.84 | ALDH1A1 (0.55) | ALDH1A1TSHRFDPSSMN1; SMN2LMNA | |
| SCHEMBL701781 | 0.82 | ALDH1A1 (0.64) | ALDH1A1TSHRFDPSSMN1; SMN2LMNA | |
| SCHEMBL10029177 | 0.76 | CA2 (0.37) | ALDH1A1MAPTHTTTUBB1KDM4E | |
| SCHEMBL703866 | 0.74 | ALDH1A1 (0.62) | ALDH1A1TSHRFDPSSMN1; SMN2LMNA | |
| 3,4-Dimethoxybenzaldehyde SCHEMBL2370925 | 0.72 | ALDH1A1 (0.74) | ALDH1A1TSHRFDPSSMN1; SMN2LMNA | |
| 3,4-Dimethoxybenzaldehyde SCHEMBL13290624 | 0.69 | ALDH1A1 (0.81) | ALDH1A1TSHRFDPSSMN1; SMN2LMNA | |
| 3,4-Dimethoxybenzaldehyde SCHEMBL2370931 | 0.69 | ALDH1A1 (0.81) | ALDH1A1TSHRFDPSSMN1; SMN2LMNA | |
| SCHEMBL10029176 | 0.66 | PDE4B (0.38) | PDE4BCA1CA2 | |
| SCHEMBL30028779 | 0.63 | ALDH1A1 (0.61) | ALDH1A1FDPSSMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160264524-A1 | SUBSTITUTED ISOINDOLINE-1,3-DIONE DERIVATIVES | CONCERT PHARMACEUTICALS INC (US) | 2016-09-15 | — | — | US | disclosed |
| US-9296689-B2 | Substituted isoindoline-1,3-dione derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2016-03-29 | — | — | US | disclosed |
| US-20150105438-A1 | SUBSTITUTED ISOINDOLINE-1,3-DIONE DERIVATIVES | CONCERT PHARMACEUTICALS, INC. (US) | 2015-04-16 | — | — | US | disclosed |
| US-8883843-B2 | Substituted isoindoline-1,3-dione derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2014-11-11 | — | — | US | disclosed |
| US-20130345282-A1 | SUBSTITUTED ISOINDOLINE-1,3-DIONE DERIVATIVES | CONCERT PHARMACEUTICALS, INC. (US) | 2013-12-26 | — | — | US | disclosed |
| US-8404737-B2 | Substituted isoindoline-1,3-dione derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2013-03-26 | — | — | US | disclosed |
| US-8404737-B2 | Substituted isoindoline-1,3-dione derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2013-03-26 | — | — | US | disclosed |
| US-20120252864-A1 | SUBSTITUTED ISOINDOLINE-1,3-DIONE DERIVATIVES | CONCERT PHARMACEUTICALS INC. | 2012-10-04 | — | — | US | disclosed |
| US-20120252864-A1 | SUBSTITUTED ISOINDOLINE-1,3-DIONE DERIVATIVES | CONCERT PHARMACEUTICALS INC. | 2012-10-04 | — | — | US | disclosed |
| US-8124646-B2 | Substituted isoindoline-1,3-dione derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2012-02-28 | — | — | US | disclosed |
| US-8124646-B2 | Substituted isoindoline-1,3-dione derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2012-02-28 | — | — | US | disclosed |
| US-20100324108-A1 | SUBSTITUTED ISOINDOLINE-1,3-DIONE DERIVATIVES | CONCERT PHARMACEUTICALS INC. | 2010-12-23 | — | — | US | disclosed |
| US-20100324108-A1 | SUBSTITUTED ISOINDOLINE-1,3-DIONE DERIVATIVES | CONCERT PHARMACEUTICALS INC. | 2010-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130345282-A1 | SUBSTITUTED ISOINDOLINE-1,3-DIONE DERIVATIVES | QDPR, IDO1, ADRA1D | ALDH1A1 4/4885TSHR 4771/4885FDPS 173/4885 |
| US-20120252864-A1 | SUBSTITUTED ISOINDOLINE-1,3-DIONE DERIVATIVES | QDPR, IDO1, ADRA1D | ALDH1A1 4/4885TSHR 4771/4885FDPS 173/4885 |
| US-20160264524-A1 | SUBSTITUTED ISOINDOLINE-1,3-DIONE DERIVATIVES | QDPR, IDO1, ADRA1D | ALDH1A1 4/4885TSHR 4771/4885FDPS 173/4885 |
| US-20150105438-A1 | SUBSTITUTED ISOINDOLINE-1,3-DIONE DERIVATIVES | QDPR, IDO1, ADRA1D | ALDH1A1 4/4885TSHR 4771/4885FDPS 173/4885 |
| US-20100324108-A1 | SUBSTITUTED ISOINDOLINE-1,3-DIONE DERIVATIVES | QDPR, IDO1, ADRA1D | ALDH1A1 4/4885TSHR 4771/4885FDPS 173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.