Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | FDPS | P14324 | 1/20 | 0.58 |
| ▸ | TTR | P02766 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.52 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.52 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.52 |
| ▸ | ABAT | P80404 | 1/20 | 0.52 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 3,4-Dimethoxybenzaldehyde SCHEMBL13290624 | 0.96 | ALDH1A1 (0.81) | ALDH1A1TSHRFDPSTTRHPGD | |
| 3,4-Dimethoxybenzaldehyde SCHEMBL2370931 | 0.96 | ALDH1A1 (0.81) | ALDH1A1TSHRFDPSTTRHPGD | |
| 3,4-Dimethoxybenzaldehyde SCHEMBL2529644 | 0.86 | ALDH1A1 (0.55) | ALDH1A1TSHRFDPSTTRHPGD | |
| SCHEMBL703866 | 0.86 | ALDH1A1 (0.62) | ALDH1A1TSHRFDPSHPGDTDP1 | |
| 3,4-Dimethoxybenzaldehyde SCHEMBL29364994 | 0.85 | ALDH1A1 (1.00) | ALDH1A1TSHRFDPSTTRHPGD | |
| 3,4-Dimethoxybenzaldehyde SCHEMBL25202 | 0.85 | ALDH1A1 (1.00) | ALDH1A1TSHRFDPSTTRHPGD | |
| 3,4-Dimethoxybenzaldehyde SCHEMBL5308959 | 0.85 | ALDH1A1 (1.00) | ALDH1A1TSHRFDPSTTRHPGD | |
| 3,4-Dimethoxybenzaldehyde SCHEMBL1330962 | 0.85 | ALDH1A1 (1.00) | ALDH1A1TSHRFDPSTTRHPGD | |
| SCHEMBL15580939 | 0.85 | ALDH1A1 (0.53) | ALDH1A1TSHRFDPSTTRHPGD | |
| SCHEMBL702720 | 0.84 | ALDH1A1 (0.53) | ALDH1A1TSHRFDPSTTRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116969936-A | BCL-2 inhibitors | 百济神州有限公司 | 2023-10-31 | — | — | CN | disclosed |
| CN-116802179-A | BCL-2 inhibitors | 百济神州有限公司 | 2023-09-22 | — | — | CN | disclosed |
| EP-4136084-A1 | BCL-2 INHIBITOR | BeiGene, Ltd. (KY) | 2023-02-22 | — | — | EP | disclosed |
| US-8575221-B2 | Derivatives of dimethylcurcumin | CONCERT PHARMACEUTICALS, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-8084464-B2 | Tetrahydroisoquinoline derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2011-12-27 | — | — | US | disclosed |
| US-8084464-B2 | Tetrahydroisoquinoline derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2011-12-27 | — | — | US | disclosed |
| US-20110257271-A1 | DERIVATIVES OF DIMETHYLCURCUMIN | CONCERT PHARMACEUTICALS, INC. | 2011-10-20 | — | — | US | disclosed |
| WO-2011116066-A1 | DERIVATIVES OF DIMETHYLCURCUMIN | CONCERT PHARMACEUTICALS, INC. (US) | 2011-09-22 | — | — | WO | disclosed |
| EP-2231155-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | Concert Pharmaceuticals Inc. (US) | 2010-09-29 | — | — | EP | disclosed |
| US-20100160351-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING HYPERURICEMIA AND RELATED DISORDERS | NUON THERAPEUTICS, INC. (US) | 2010-06-24 | — | — | US | disclosed |
| US-20100158905-A1 | COMBINATION THERAPY OF ARTHRITIS WITH TRANILAST | NUON THERAPEUTICS, INC. (US) | 2010-06-24 | — | — | US | disclosed |
| US-20090192188-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | SUN PHARMACEUTICAL INDUSTRIES, INC. | 2009-07-30 | — | — | US | disclosed |
| US-20090192188-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | SUN PHARMACEUTICAL INDUSTRIES, INC. | 2009-07-30 | — | — | US | disclosed |
| WO-2009079637-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | CONCERT PHARMACEUTICALS, INC. (US) | 2009-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192188-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES | HCRTR2, HCRTR1, OXTR | ALDH1A1 1612/4885TSHR 932/4885FDPS 4517/4885 |
| US-20110257271-A1 | DERIVATIVES OF DIMETHYLCURCUMIN | UROD, UGT1A1, UGT1A3 | ALDH1A1 319/4885TSHR 4266/4885FDPS 153/4885 |
| US-20100158905-A1 | COMBINATION THERAPY OF ARTHRITIS WITH TRANILAST | PTGS2, PTGES2, PTGES | ALDH1A1 351/4885TSHR 2986/4885FDPS 1743/4885 |
| US-20100160351-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING HYPERURICEMIA AND RELATED DISORDERS | XDH, SLC10A1, SLC10A6 | ALDH1A1 488/4885TSHR 1570/4885FDPS 1369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.