SCHEMBL7048966

SCHEMBL7048966

O=C(NO)C(O)COc1ccccc1-c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 3/20 0.52
ADRB1 P08588 1/20 0.52
L3MBTL1 Q9Y468 3/20 0.50
TDP1 Q9NUW8 2/20 0.50
ALDH1A1 P00352 4/20 0.49
SMN1; SMN2 Q16637 3/20 0.49
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
KDM4E B2RXH2 7/20 0.49
HTT P42858 3/20 0.48
LMNA P02545 2/20 0.48
MAPK1 P28482 2/20 0.48
MAPT P10636 2/20 0.48
USP2 O75604 1/20 0.48
RXRA P19793 1/20 0.47
RXRB P28702 1/20 0.47
RXRG P48443 1/20 0.47
PKM P14618 1/20 0.46
ADRA1A P35348 1/20 0.44
TP53 P04637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7047544 0.88 L3MBTL1 (0.55) ADRB2ADRB1L3MBTL1TDP1ALDH1A1
SCHEMBL6230392 0.84 L3MBTL1 (0.58) ADRB2ADRB1L3MBTL1TDP1ALDH1A1
SCHEMBL7048964 0.79 MMP3 (0.55) SMN1; SMN2MAPT
SCHEMBL7041403 0.75 L3MBTL1 (0.64) L3MBTL1TDP1ALDH1A1SMN1; SMN2MEN1
SCHEMBL1151623 0.74 ADRB2 (0.56) ADRB2ADRB1L3MBTL1TDP1ALDH1A1
SCHEMBL12473595 0.74 ADRB2 (0.61) ADRB2ADRB1L3MBTL1TDP1ALDH1A1
SCHEMBL10408230 0.74 ADRB2 (0.64) ADRB2ADRB1L3MBTL1TDP1ALDH1A1
SCHEMBL7041841 0.73 MMP3 (0.63) ADRB2L3MBTL1TDP1ALDH1A1SMN1; SMN2
SCHEMBL15677631 0.72 ADRB2 (0.65) ADRB2ADRB1L3MBTL1TDP1ALDH1A1
SCHEMBL772820 0.72 ADRB2 (0.61) ADRB2ADRB1L3MBTL1TDP1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0874808-B1 BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES ABBOTT LAB (US) 2003-04-09 EP claimed
EP-0874808-A1 BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES Abbott Laboratories (US) 1998-11-04 EP claimed
WO-1997018188-A1 BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES ABBOTT LABORATORIES (US) 1997-05-22 WO claimed
EP-0874808-B1 BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES ABBOTT LAB (US) 2003-04-09 EP disclosed
EP-0874808-A1 BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES Abbott Laboratories (US) 1998-11-04 EP disclosed
US-5665777-A ANTIINFLAMMATORY AGENTS ABBOTT LABORATORIES (US) 1997-09-09 US disclosed
WO-1997018188-A1 BIPHENYL HYDROXAMATE INHIBITORS OF MATRIX METALLOPROTEINASES ABBOTT LABORATORIES (US) 1997-05-22 WO disclosed