Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11334284 | 0.98 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL423622 | 0.93 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL9435490 | 0.93 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL4325251 | 0.89 | ALDH1A1 (0.58) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL9956852 | 0.84 | NPC1 (0.58) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL7055583 | 0.81 | PAK1 (0.44) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL29731549 | 0.79 | SMN1; SMN2 (0.45) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL11821001 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL3691473 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 | |
| SCHEMBL5586189 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2NPC1RAB9AMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101257948-A | Pyrimidine-fused diazepine derivatives and indole-fused pteridines | ATTENUON LLC (US) | 2008-09-03 | — | — | CN | disclosed |
| US-6818648-B2 | PSYCHOLOGICAL DISORDERS; ANXIOLYTIC AGENTS; ANTIDEPRESSANTS; EATING DISORDERS; ALCOHOLISM; DRUG ABUSE; ANTIINFLAMMATORY AGENTS | BRISTOL-MYERS SQUIBB PHARMA | 2004-11-16 | — | — | US | disclosed |
| US-20030191125-A1 | Aryloxy- and arylthiosubstituted pyrimidines and triazines and derivatives thereof | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-10-09 | — | — | US | disclosed |
| US-20020040026-A1 | Aryloxy-and arylthiosubstituted pyrimidines and triazines and derivatives thereof | DUPONT PHARMACEUTICALS COMPANY | 2002-04-04 | — | — | US | disclosed |
| US-6326368-B1 | PSYCHOLOGICAL DISORDERS | DUPONT PHARMACEUTICALS COMPANY | 2001-12-04 | — | — | US | disclosed |
| EP-0920318-A4 | ARYLOXY- AND ARYLTHIOSUBSTITUTED PYRIMIDINES AND TRIAZINES AND DERIVATIVES THEREOF | DU PONT PHARM CO (US) | 2000-03-15 | — | — | EP | disclosed |
| EP-0920318-A1 | ARYLOXY- AND ARYLTHIOSUBSTITUTED PYRIMIDINES AND TRIAZINES AND DERIVATIVES THEREOF | Du Pont Pharmaceuticals Company (US) | 1999-06-09 | — | — | EP | disclosed |
| WO-1997035580-A1 | ARYLOXY- AND ARYLTHIOSUBSTITUTED PYRIMIDINES AND TRIAZINES AND DERIVATIVES THEREOF | DU PONT PHARMACEUTICALS COMPANY (US) | 1997-10-02 | — | — | WO | disclosed |
| US-5426090-A | Herbicides | SHELL RESEARCH LIMITED (GB) | 1995-06-20 | — | — | US | disclosed |
| EP-0431707-A2 | Heterocyclic compounds | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1991-06-12 | — | — | EP | disclosed |
| US-4888047-A | FOR ANNUAL AND PERENNIAL GRASSES AND BROADLEAF WEEDS; POSTEMERGENCE | ICI AMERICAS INC. (US) | 1989-12-19 | — | — | US | disclosed |
| US-4888047-A | FOR ANNUAL AND PERENNIAL GRASSES AND BROADLEAF WEEDS; POSTEMERGENCE | ICI AMERICAS INC. (US) | 1989-12-19 | — | — | US | disclosed |
| EP-0219835-A3 | ACYLAMINOARYLOXY AND ARYLTHIO PYRIMIDINES | STAUFFER CHEMICAL COMPANY (US) | 1988-02-10 | — | — | EP | disclosed |
| EP-0219835-A3 | ACYLAMINOARYLOXY AND ARYLTHIO PYRIMIDINES | STAUFFER CHEMICAL COMPANY (US) | 1988-02-10 | — | — | EP | disclosed |
| EP-0219835-A2 | Acylaminoaryloxy and arylthio pyrimidines | STAUFFER CHEMICAL COMPANY (US) | 1987-04-29 | — | — | EP | disclosed |
| EP-0219835-A2 | Acylaminoaryloxy and arylthio pyrimidines | STAUFFER CHEMICAL COMPANY (US) | 1987-04-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030191125-A1 | Aryloxy- and arylthiosubstituted pyrimidines and triazines and derivatives thereof | PARL, HTR5A, PSEN2 | SMN1; SMN2 3243/4885NPC1 2910/4885RAB9A 2435/4885 |
| US-20020040026-A1 | Aryloxy-and arylthiosubstituted pyrimidines and triazines and derivatives thereof | PARL, HTR5A, PSEN2 | SMN1; SMN2 3224/4885NPC1 2930/4885RAB9A 2452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.