Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.52 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5214643 | 0.89 | MCHR1 (0.59) | L3MBTL1MBTD1L3MBTL3MAPK1HSD17B10 | |
| SCHEMBL9636512 | 0.89 | MCHR1 (0.58) | MCHR1NOTUMHRH4 | |
| SCHEMBL27752849 | 0.89 | MCHR1 (0.58) | MCHR1NOTUMHRH4 | |
| SCHEMBL5258684 | 0.85 | LTA4H (0.55) | MCHR1EPHX2SMN1; SMN2LMNAME3 | |
| SCHEMBL8728954 | 0.82 | ADRB1 (0.50) | L3MBTL1L3MBTL3MCHR1SMN1; SMN2MEN1 | |
| SCHEMBL5541618 | 0.82 | HRH4 (0.39) | L3MBTL1L3MBTL3MCHR1HRH4 | |
| SCHEMBL3440289 | 0.82 | MAPT (0.55) | L3MBTL1L3MBTL3ALOX15MAPK1HSD17B10 | |
| SCHEMBL8728952 | 0.81 | L3MBTL3 (0.40) | L3MBTL1L3MBTL3MCHR1SMN1; SMN2KMT2A | |
| SCHEMBL5537153 | 0.81 | ME3 (0.52) | L3MBTL1L3MBTL3MCHR1SMN1; SMN2MEN1 | |
| SCHEMBL21590255 | 0.81 | NPY5R (0.46) | L3MBTL1L3MBTL3MCHR1KMT2ANPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10669274-B2 | Azaphenalene-3-one derivative, preparation method therefor, and application therof | SUZHOU KANGRUN PHARMACEUTICALS INC. (CN) | 2020-06-02 | — | — | US | claimed |
| US-20200031828-A1 | AZAPHENALENE-3-ONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEROF | SUZHOU KANGRUN PHARMACEUTICALS INC. (CN) | 2020-01-30 | — | — | US | claimed |
| CN-106883232-B | A kind of derivative and the preparation method and application thereof of non-that alkene -3- ketone of azepine | 苏州康润医药有限公司 | 2019-01-22 | — | — | CN | claimed |
| CN-106883232-A | A kind of derivative of non-that ketone of alkene 3 of azepine and preparation method and application | 苏州康润医药有限公司 | 2017-06-23 | — | — | CN | claimed |
| EP-4169919-A1 | PYRAZOLO[3,4-D]PYRIMIDINE-3-KETONE DERIVATIVE AS WEE-1 INHIBITOR | Wigen Biomedicine Technology (Shanghai) Co., Ltd. (CN) | 2023-04-26 | — | — | EP | disclosed |
| US-20230109839-A1 | THERAPEUTIC AGENT FOR TAUOPATHIES | Sumitomo Pharma Co., Ltd. (JP) | 2023-04-13 | — | — | US | disclosed |
| EP-4104861-A1 | THERAPEUTIC AGENT FOR TAUOPATHIES | Sumitomo Pharma Co., Ltd. (JP) | 2022-12-21 | — | — | EP | disclosed |
| US-10874670-B2 | Substituted fused heteroaromatic compounds as kinase inhibitors and the use thereof | IMPACT THERAPEUTICS, INC. (CN) | 2020-12-29 | — | — | US | disclosed |
| US-10669274-B2 | Azaphenalene-3-one derivative, preparation method therefor, and application therof | SUZHOU KANGRUN PHARMACEUTICALS INC. (CN) | 2020-06-02 | — | — | US | disclosed |
| US-10669274-B2 | Azaphenalene-3-one derivative, preparation method therefor, and application therof | SUZHOU KANGRUN PHARMACEUTICALS INC. (CN) | 2020-06-02 | — | — | US | disclosed |
| US-20200031828-A1 | AZAPHENALENE-3-ONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEROF | SUZHOU KANGRUN PHARMACEUTICALS INC. (CN) | 2020-01-30 | — | — | US | disclosed |
| US-20200031828-A1 | AZAPHENALENE-3-ONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEROF | SUZHOU KANGRUN PHARMACEUTICALS INC. (CN) | 2020-01-30 | — | — | US | disclosed |
| US-7358370-B2 | Anticancer, inflammation, arthritis, angiogenesis, neurodegenerative diseases, fungal infections, malaria; Heat-shock protein 90 inhibitors; 4-(6,6-Dimethyl-4-oxo-3-methyl-4,5,6,7-tetrahydro-indazol-1-yl)-2-(3,4,5-trimethoxyanilino)-benzamide | SERENEX, INC. (US) | 2008-04-15 | — | — | US | disclosed |
| WO-2007020502-A2 | CANNABINOID RECEPTOR LIGANDS AND USES THEREOF | PHARMACIA & UPJOHN COMPANY LLC (US) | 2007-02-22 | — | — | WO | disclosed |
| CN-1257901-C | Tetrahydroquinolinone piperidine compounds and preparation method and application thereof | SHANGHAI INST OF PHARMACOLOGY (CN) | 2006-05-31 | — | — | CN | disclosed |
| WO-2004024728-A2 | PYRAZOLO[3,4-B]PYRIDINE COMPOUNDS, AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-03-25 | — | — | WO | disclosed |
| CN-1417209-A | Tetrahydroquinolinone piperidine compounds and preparation method and application thereof | SHANGHAI INST OF PHARMACOLOGY (CN) | 2003-05-14 | — | — | CN | disclosed |
| EP-1301464-A1 | BIPHENYLCARBOXYLIC ACID AMIDES, PRODUCTION THEREOF AND USE THEREOF AS MEDICAMENTS | Boehringer Ingelheim Pharma KG (DE) | 2003-04-16 | — | — | EP | disclosed |
| US-20020032238-A1 | Biphenylcarboxylic acid amides, the preparation thereof and the use thereof as medicaments | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-03-14 | — | — | US | disclosed |
| WO-2002004403-A1 | BIPHENYLCARBOXYLIC ACID AMIDES, PRODUCTION THEREOF AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230109839-A1 | THERAPEUTIC AGENT FOR TAUOPATHIES | MAPT, PSEN1, PSEN2 | L3MBTL1 3392/4885MBTD1 3702/4885L3MBTL3 3594/4885 |
| US-20020032238-A1 | Biphenylcarboxylic acid amides, the preparation thereof and the use thereof as medicaments | MTTP, CETP, FABP1 | L3MBTL1 3333/4885MBTD1 487/4885L3MBTL3 4711/4885 |
| US-10874670-B2 | Substituted fused heteroaromatic compounds as kinase inhibitors and the use thereof | CHEK1, CHEK2, CDK1 | L3MBTL1 712/4885MBTD1 2035/4885L3MBTL3 788/4885 |
| US-20200031828-A1 | AZAPHENALENE-3-ONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND APPLICATION THEROF | PARP1, PARP11, PARP8 | L3MBTL1 4047/4885MBTD1 1783/4885L3MBTL3 4565/4885 |
| US-10669274-B2 | Azaphenalene-3-one derivative, preparation method therefor, and application therof | PARP1, PARP11, PARP8 | L3MBTL1 4047/4885MBTD1 1783/4885L3MBTL3 4565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.