Dimethylamine

Dimethylamine

SCHEMBL7053166

CNC.NC(=O)C(Cl)c1ccccc1

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.43
ALOX5 P09917 1/20 0.43
EPHX1 P07099 1/20 0.43
KMT2A Q03164 2/20 0.42
CTSD P07339 1/20 0.42
BCAT2 O15382 1/20 0.42
HPGD P15428 1/20 0.41
CYP2D6 P10635 1/20 0.40
SRC P12931 1/20 0.40
SLC6A3 Q01959 1/20 0.40
HDAC3 O15379 1/20 0.39
HDAC4 P56524 1/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC10 Q969S8 1/20 0.39
HDAC11 Q96DB2 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
HDAC9 Q9UKV0 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1091960 0.92 EPHX1 (0.48) LMNAALOX5EPHX1KMT2ACTSD
SCHEMBL3767845 0.80 PTGS2 (0.50) LMNATSHR
SCHEMBL6039993 0.78 LMNA (0.53) LMNAKMT2ACTSDHPGDSLC6A3
Benzene SCHEMBL27730624 0.78 CYP2D6 (0.46) LMNAALOX5HPGDCYP2D6SRC
SCHEMBL7391810 0.76 ALOX5 (0.47) LMNAALOX5EPHX1KMT2ABCAT2
SCHEMBL6213432 0.76 RXRA (0.46) EPHX1HDAC8
SCHEMBL7282243 0.75 ALOX5 (0.48) LMNAALOX5KMT2AHPGDMEN1
SCHEMBL356020 0.74 LMNA (0.47) LMNAKMT2AHPGDCYP2D6SRC
SCHEMBL5089604 0.73 LMNA (0.44) LMNAALOX5EPHX1KMT2ACTSD
SCHEMBL10090088 0.73 LMNA (0.44) LMNAALOX5EPHX1KMT2ACTSD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1086081-A1 QUARTERNARY AMMONIUM COMPOUNDS AS ANTI-TUSSIVE AGENTS Nortran Pharmaceuticals Inc. (CA) 2001-03-28 EP claimed
WO-1999064398-A1 QUARTERNARY AMMONIUM COMPOUNDS AS ANTI-TUSSIVE AGENTS NORTRAN PHARMACEUTICALS, INC. (CA) 1999-12-16 WO claimed
WO-2013034910-A1 INHALABLE COMPOSITIONS VERONA PHARMA PLC (GB) 2013-03-14 WO disclosed
EP-1009397-B1 USE OF N,N-BIS (PHENYLCARBAMOYLMETHYL) DIMETHYLAMMONIUM CHLORIDE AND DERIVATIVES IN THE TREATMENT OF CHRONIC PAIN UCB FARCHIM SA (CH) 2003-04-23 EP disclosed
EP-1009397-B1 USE OF N,N-BIS (PHENYLCARBAMOYLMETHYL) DIMETHYLAMMONIUM CHLORIDE AND DERIVATIVES IN THE TREATMENT OF CHRONIC PAIN UCB FARCHIM SA (CH) 2003-04-23 EP disclosed
EP-1086081-A1 QUARTERNARY AMMONIUM COMPOUNDS AS ANTI-TUSSIVE AGENTS Nortran Pharmaceuticals Inc. (CA) 2001-03-28 EP disclosed
CN-1276722-A N, N-bis (phenylcarbamoylmethyl) dimethylammonium chloride and derivatives thereof for the treatment of pain NORTRAN PHARMACEUTICALS INC (CA) 2000-12-13 CN disclosed
EP-1009397-A2 N,N-BIS (PHENYLCARBAMOYLMETHYL) DIMETHYLAMMONIUM CHLORIDE AND DERIVATIVES IN THE TREATMENT OF PAIN Nortran Pharmaceuticals Inc. (CA) 2000-06-21 EP disclosed
EP-1009397-A2 N,N-BIS (PHENYLCARBAMOYLMETHYL) DIMETHYLAMMONIUM CHLORIDE AND DERIVATIVES IN THE TREATMENT OF PAIN Nortran Pharmaceuticals Inc. (CA) 2000-06-21 EP disclosed
WO-1999064398-A1 QUARTERNARY AMMONIUM COMPOUNDS AS ANTI-TUSSIVE AGENTS NORTRAN PHARMACEUTICALS, INC. (CA) 1999-12-16 WO disclosed
WO-1999011252-A3 N,N-BIS (PHENYLCARBAMOYLMETHYL) DIMETHYLAMMONIUM CHLORIDE AND DERIVATIVES IN THE TREATMENT OF PAIN NORTRAN PHARMACEUTICALS INC (CA) 1999-05-06 WO disclosed
WO-1999011252-A2 N,N-BIS (PHENYLCARBAMOYLMETHYL) DIMETHYLAMMONIUM CHLORIDE AND DERIVATIVES IN THE TREATMENT OF PAIN NORTRAN PHARMACEUTICALS, INC. (CA) 1999-03-11 WO disclosed
WO-1999011252-A2 N,N-BIS (PHENYLCARBAMOYLMETHYL) DIMETHYLAMMONIUM CHLORIDE AND DERIVATIVES IN THE TREATMENT OF PAIN NORTRAN PHARMACEUTICALS, INC. (CA) 1999-03-11 WO disclosed