Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 11/20 | 0.53 |
| ▸ | THRB | P10828 | 7/20 | 0.53 |
| ▸ | THRA | P10827 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL282114 | 0.90 | THRB (0.51) | RORCTHRBTHRA | |
| SCHEMBL7054452 | 0.88 | THRB (0.57) | RORCTHRBTHRA | |
| SCHEMBL282476 | 0.88 | RORC (0.66) | RORCTHRBTHRA | |
| SCHEMBL10239573 | 0.82 | MAPT (0.58) | KMT2AMEN1MAPT | |
| SCHEMBL282165 | 0.77 | THRB (0.53) | RORCTHRBTHRA | |
| SCHEMBL6368421 | 0.77 | RORC (0.64) | RORCTHRBTHRA | |
| SCHEMBL5619231 | 0.76 | THRB (0.73) | RORCTHRBTHRA | |
| SCHEMBL2788081 | 0.76 | THRB (0.73) | RORCTHRBTHRA | |
| SCHEMBL7053361 | 0.74 | NR3C1 (0.53) | KMT2AMAPT | |
| SCHEMBL282237 | 0.74 | THRB (0.51) | RORCTHRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102739-B1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KAROBIO AB (SE) | 2003-04-23 | — | — | EP | disclosed |
| US-6492424-B1 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2002-12-10 | — | — | US | disclosed |
| EP-1102739-A1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007972-A1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KARO BIO AB (SE) | 2000-02-17 | — | — | WO | disclosed |