Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GALR2 | O43603 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | CCR6 | P51684 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703943 | 0.84 | KMT2A (0.43) | HPGDALDH1A1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL7689927 | 0.78 | ALDH1A1 (0.38) | HPGDALDH1A1POLBLMNASMN1; SMN2 | |
| SCHEMBL7135043 | 0.78 | ALDH1A1 (0.39) | HPGDALDH1A1POLBLMNASMN1; SMN2 | |
| SCHEMBL2388710 | 0.78 | TSHR (0.50) | ALDH1A1POLBSMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL8963317 | 0.77 | KDM4E (0.40) | ALDH1A1POLBSMN1; SMN2CYP1A2KMT2A | |
| SCHEMBL19332726 | 0.77 | CCNC (0.44) | ALDH1A1LMNASMN1; SMN2MAPTKDM4E | |
| SCHEMBL18040285 | 0.76 | AR (0.54) | KMT2AMEN1MAPTRAB9AGAA | |
| SCHEMBL16693014 | 0.76 | AR (0.54) | KMT2AMEN1MAPTRAB9AGAA | |
| SCHEMBL4107701 | 0.76 | CYP1A2 (0.52) | HPGDALDH1A1POLBLMNACYP1A2 | |
| SCHEMBL11649335 | 0.75 | CYP1A2 (0.50) | HPGDALDH1A1POLBLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11840529-B2 | Substituted pyrimidines as LRKK2 inhibitors | DENALI THERAPEUTICS INC. (US) | 2023-12-12 | — | — | US | disclosed |
| US-20210300914-A1 | SUBSTITUTED PYRIMIDINES AS LRKK2 INHIBITORS | DENALI THERAPEUTICS INC. (US) | 2021-09-30 | — | — | US | disclosed |
| US-11028080-B2 | Substituted pyrimidines as LRKK2 inhibitors | DENALI THERAPEUTICS INC. (US) | 2021-06-08 | — | — | US | disclosed |
| US-20190084975-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | DENALI THERAPEUTICS INC. | 2019-03-21 | — | — | US | disclosed |
| WO-2017156493-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | DENALI THERAPEUTICS INC. (US) | 2017-09-14 | — | — | WO | disclosed |
| WO-2003020877-A2 | STAINING AND SORTING GENOMES AND CHROMOSOMES USING SEQUENCE-SPECIFIC POLYAMIDES | PHARMACIA CORPORATION (US) | 2003-03-13 | — | — | WO | disclosed |
| EP-0003663-A2 | Amino-substituted phenyl and heteroaryl compounds, process for their preparation and pharmaceutical compositions containing them | AMERICAN CYANAMID COMPANY (US) | 1979-08-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11028080-B2 | Substituted pyrimidines as LRKK2 inhibitors | LRRK2, DTYMK, LMTK2 | HPGD 1818/4885ALDH1A1 4020/4885POLB 1012/4885 |
| US-11840529-B2 | Substituted pyrimidines as LRKK2 inhibitors | LRRK2, DTYMK, LMTK2 | HPGD 1818/4885ALDH1A1 4020/4885POLB 1012/4885 |
| US-20210300914-A1 | SUBSTITUTED PYRIMIDINES AS LRKK2 INHIBITORS | LRRK2, DTYMK, LMTK2 | HPGD 1818/4885ALDH1A1 4020/4885POLB 1012/4885 |
| US-20190084975-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | LRRK2, SNCA, PARK7 | HPGD 2233/4885ALDH1A1 3725/4885POLB 1026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.