Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27320863 | 0.78 | CYP11B2 (0.52) | ALDH1A1CYP11B2CYP11B1CHRNB2CHRNA4 | |
| SCHEMBL289623 | 0.75 | — | — | |
| SCHEMBL2963738 | 0.74 | L3MBTL1 (0.42) | ALDH1A1KMT2AMEN1LMNANPC1 | |
| SCHEMBL26123968 | 0.73 | MAPT (0.44) | ALDH1A1CYP11B2CYP11B1KMT2AMEN1 | |
| SCHEMBL256706 | 0.71 | CHRNB2 (0.62) | ALDH1A1CYP11B2CYP11B1CHRNB2CHRNA4 | |
| SCHEMBL22714727 | 0.71 | CHRNB2 (0.62) | ALDH1A1CYP11B2CYP11B1CHRNB2CHRNA4 | |
| SCHEMBL2305391 | 0.71 | CHRNB2 (0.62) | ALDH1A1CYP11B2CYP11B1CHRNB2CHRNA4 | |
| SCHEMBL29511509 | 0.71 | CHRNB2 (0.62) | ALDH1A1CYP11B2CYP11B1CHRNB2CHRNA4 | |
| SCHEMBL5709830 | 0.71 | KMT2A (0.49) | ALDH1A1CYP11B2CYP11B1CHRNB2CHRNA4 | |
| SCHEMBL213871 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309589-A2 | UREA COMPOUNDS AND METHODS OF USES | Amgen Inc. (US) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014311-A2 | UREA COMPOUNDS AND METHODS OF USES | AMGEN INC. (US) | 2002-02-21 | — | — | WO | disclosed |
| CN-1053064-A | PROCESS FOR PREPARING HETEROCYCLIC DERIVATIVES | SANOFI SA (FR) | 1991-07-17 | — | — | CN | disclosed |