SCHEMBL7060179

SCHEMBL7060179

CN(CCOc1ccc(CC2SC(=O)CC2=O)cc1)c1ccccn1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 11/20 0.70
RARG P13631 1/20 0.62
RXRA P19793 1/20 0.62
MAPT P10636 5/20 0.48
ALDH1A1 P00352 3/20 0.48
KDM4E B2RXH2 2/20 0.48
PKM P14618 2/20 0.48
HTT P42858 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
KMT2A Q03164 3/20 0.48
PPARA Q07869 3/20 0.44
MEN1 O00255 2/20 0.43
CYP3A4 P08684 2/20 0.43
CYP2C9 P11712 2/20 0.43
CYP2C19 P33261 2/20 0.43
GMNN O75496 1/20 0.43
EGFR P00533 1/20 0.43
LMNA P02545 1/20 0.43
ADORA3 P0DMS8 1/20 0.43
CYP2D6 P10635 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2615497 0.85 PPARG (0.54) PPARGRARGRXRAMAPTALDH1A1
Rosiglitazone SCHEMBL7052472 0.82 PPARG (1.00) PPARGRARGRXRAMAPTALDH1A1
Rosiglitazone SCHEMBL2355017 0.82 PPARG (1.00) PPARGRARGRXRAMAPTALDH1A1
Rosiglitazone SCHEMBL11957687 0.82 PPARG (1.00) PPARGRARGRXRAMAPTALDH1A1
SCHEMBL13422203 0.82 PPARG (0.71) PPARGRARGRXRAMAPTALDH1A1
Rosiglitazone SCHEMBL5169 0.82 PPARG (1.00) PPARGRARGRXRAMAPTALDH1A1
Rosiglitazone SCHEMBL29530259 0.82 PPARG (1.00) PPARGRARGRXRAMAPTALDH1A1
Rosiglitazone SCHEMBL14383595 0.82 PPARG (0.73) PPARGRARGRXRAMAPTALDH1A1
Rosiglitazone SCHEMBL5468691 0.82 PPARG (0.98) PPARGRARGRXRAMAPTALDH1A1
Rosiglitazone SCHEMBL3377103 0.82 PPARG (0.98) PPARGRARGRXRAMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9783592-B2 Glucagon superfamily peptides exhibiting nuclear hormone receptor activity INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2017-10-10 US disclosed
US-20170283960-A1 METHOD OF DISCOVERING FLUORO-CONTAINING COMPOUNDS SHANXI CHEMICAL RESEARCH INSTITUTE CO., LTD. (CN) 2017-10-05 US disclosed
US-20160051688-A1 GLUCAGON SUPERFAMILY PEPTIDES EXHIBITING G PROTEIN-COUPLED RECEPTOR ACTIVITY UNIV INDIANA RES & TECH CORP (US) 2016-02-25 US disclosed
US-20150320871-A1 Glucagon Superfamily Peptides Exhibiting Nuclear Hormone Receptor Activity UNIV INDIANA RES & TECH CORP (US) 2015-11-12 US disclosed
US-9145451-B2 Glucagon superfamily peptides exhbiting G protein coupled receptor activity INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2015-09-29 US disclosed
US-9127088-B2 Glucagon superfamily peptides exhibiting nuclear hormone receptor activity INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2015-09-08 US disclosed
US-20150004144-A1 DIFFERENTIATION INTO BROWN ADIPOCYTES THE GENERAL HOSPITAL CORPORATION (US) 2015-01-01 US disclosed
US-20140066369-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto ARENA PHARMACEUTICALS, INC. (US) 2014-03-06 US disclosed
US-20140051629-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2014-02-20 US disclosed
US-20140038889-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto ARENA PHARMACEUTICALS, INC. (US) 2014-02-06 US disclosed
US-20140018371-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto ARENA PHARMACEUTICALS, INC. (US) 2014-01-16 US disclosed
US-20130123178-A1 GLUCAGON SUPERFAMILY PEPTIDES EXHIBITING NUCLEAR HORMONE RECEPTOR ACTIVITY INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) 2013-05-16 US disclosed
US-20130116172-A1 GLUCAGON SUPERFAMILY PEPTIDES EXHBITING G PROTEIN COUPLED RECEPTOR ACTIVITY MARCADIA BIOTECH, INC. (US) 2013-05-09 US disclosed
US-20130023494-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2013-01-24 US disclosed
US-20100016292-A1 INHIBITORS OF LETHAL FACTOR PROTEASE THE BURNHAM INSTITUTE (US) 2010-01-21 US disclosed
US-20030092742-A1 Process for the preparation of thiazolidinedione derivatives SMITHKLINE BEECHAM P.L.C. 2003-05-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130116172-A1 GLUCAGON SUPERFAMILY PEPTIDES EXHBITING G PROTEIN COUPLED RECEPTOR ACTIVITY GCGR, GLP1R, GIPR PPARG 155/4885RARG 771/4885RXRA 825/4885
US-20140038889-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto GPR119, GLP1R, DPP4 PPARG 50/4885RARG 704/4885RXRA 1062/4885
US-20030092742-A1 Process for the preparation of thiazolidinedione derivatives NAT1, CYP2F1, TALDO1 PPARG 528/4885RARG 1932/4885RXRA 1769/4885
US-20130023494-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO GPR119, SLC5A2, SLC5A1 PPARG 85/4885RARG 474/4885RXRA 822/4885
US-20150320871-A1 Glucagon Superfamily Peptides Exhibiting Nuclear Hormone Receptor Activity GIPR, GLP1R, GCGR PPARG 32/4885RARG 297/4885RXRA 161/4885
US-20160051688-A1 GLUCAGON SUPERFAMILY PEPTIDES EXHIBITING G PROTEIN-COUPLED RECEPTOR ACTIVITY GCGR, GLP1R, GIPR PPARG 135/4885RARG 863/4885RXRA 1041/4885
US-20130123178-A1 GLUCAGON SUPERFAMILY PEPTIDES EXHIBITING NUCLEAR HORMONE RECEPTOR ACTIVITY GIPR, GLP1R, GCGR PPARG 32/4885RARG 297/4885RXRA 161/4885
US-20140051629-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO GPR119, GLP1R, DPP4 PPARG 45/4885RARG 744/4885RXRA 905/4885
US-20100016292-A1 INHIBITORS OF LETHAL FACTOR PROTEASE APAF1, F11, SERPINB1 PPARG 4749/4885RARG 4684/4885RXRA 3848/4885
US-20140066369-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto GPR119, GLP1R, SLC5A2 PPARG 60/4885RARG 390/4885RXRA 847/4885
US-20140018371-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto GPR119, GCGR, GLP1R PPARG 86/4885RARG 330/4885RXRA 695/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.