Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7061528 | 0.89 | ALDH1A1 (0.36) | MEN1CYP3A4CYP2C9KMT2AGAA | |
| SCHEMBL7059744 | 0.85 | GAA (0.43) | MEN1CYP3A4CYP2C9KMT2AGAA | |
| SCHEMBL6680685 | 0.77 | MEN1 (0.33) | MEN1CYP3A4CYP2C9KMT2AGAA | |
| SCHEMBL7058690 | 0.76 | GAA (0.34) | MEN1CYP3A4CYP2C9KMT2AGAA | |
| SCHEMBL7130471 | 0.76 | ALDH1A1 (0.37) | MEN1CYP3A4CYP2C9KMT2AALDH1A1 | |
| SCHEMBL7127235 | 0.76 | ADORA2A (0.33) | MEN1CYP3A4CYP2C9KMT2AL3MBTL1 | |
| SCHEMBL7120575 | 0.73 | ALDH1A1 (0.47) | MEN1CYP3A4CYP2C9KMT2AGAA | |
| SCHEMBL7116631 | 0.69 | KMT2A (0.47) | MEN1CYP3A4CYP2C9KMT2AALDH1A1 | |
| SCHEMBL6678802 | 0.69 | CMA1 (0.31) | — | |
| SCHEMBL7057681 | 0.68 | CMA1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040224951-A1 | 5,6-Fused uracil derivatives as matrix metalloproteinase inhibitors | ROARK WILLIAM HOWARD (US) | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224951-A1 | 5,6-Fused uracil derivatives as matrix metalloproteinase inhibitors | MMP9, MMP13, MMP25 | MEN1 3549/4885CYP3A4 1686/4885CYP2C9 841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.