Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | GPR18 | Q14330 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7120575 | 0.90 | ALDH1A1 (0.47) | ALDH1A1LMNAMEN1KMT2ACYP3A4 | |
| SCHEMBL7116516 | 0.87 | ALDH1A1 (0.38) | ALDH1A1LMNAMEN1KMT2ACYP3A4 | |
| SCHEMBL7061528 | 0.86 | ALDH1A1 (0.36) | ALDH1A1LMNAMEN1KMT2ACYP3A4 | |
| SCHEMBL7127235 | 0.85 | ADORA2A (0.33) | ALDH1A1MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL6788504 | 0.80 | ALDH1A1 (0.39) | ALDH1A1LMNAMEN1KMT2ACYP3A4 | |
| SCHEMBL7123002 | 0.80 | ALDH1A1 (0.38) | ALDH1A1LMNAMEN1KMT2ACYP3A4 | |
| SCHEMBL7116631 | 0.77 | KMT2A (0.47) | ALDH1A1LMNAMEN1KMT2ACYP3A4 | |
| SCHEMBL7126064 | 0.75 | L3MBTL1 (0.40) | ALDH1A1LMNAMEN1KMT2ACYP3A4 | |
| SCHEMBL7059744 | 0.72 | GAA (0.43) | ALDH1A1LMNAMEN1KMT2ACYP3A4 | |
| SCHEMBL7118338 | 0.72 | KDM4E (0.37) | ALDH1A1LMNAMAPTRXFP1PARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040224951-A1 | 5,6-Fused uracil derivatives as matrix metalloproteinase inhibitors | ROARK WILLIAM HOWARD (US) | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224951-A1 | 5,6-Fused uracil derivatives as matrix metalloproteinase inhibitors | MMP9, MMP13, MMP25 | ALDH1A1 812/4885LMNA 3842/4885MEN1 3549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.