Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | APP | P05067 | 3/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12374585 | 0.84 | ALDH1A1 (0.53) | ALDH1A1CYP3A4TDP1TSHRHSD17B10 | |
| SCHEMBL5720649 | 0.83 | ALDH1A1 (0.59) | ALDH1A1CYP3A4TDP1TSHRHSD17B10 | |
| SCHEMBL5720651 | 0.83 | ALDH1A1 (0.59) | ALDH1A1CYP3A4TDP1TSHRHSD17B10 | |
| SCHEMBL279706 | 0.81 | HTR3E (0.59) | ALDH1A1CYP3A4TSHRHTR3EHTR3B | |
| SCHEMBL28289687 | 0.79 | MEN1 (0.59) | ALDH1A1TDP1TSHRHSD17B10PTGS1 | |
| SCHEMBL23624937 | 0.78 | ALDH1A1 (0.48) | ALDH1A1CYP3A4TDP1TSHRHSD17B10 | |
| SCHEMBL28210372 | 0.78 | KDM4E (0.39) | ALDH1A1TDP1TSHRHSD17B10HTT | |
| SCHEMBL12154783 | 0.78 | HTR3E (0.41) | ALDH1A1TSHRHSD17B10HTR3EHTR3B | |
| SCHEMBL5720573 | 0.77 | MEN1 (0.52) | ALDH1A1CYP3A4TDP1TSHRHSD17B10 | |
| SCHEMBL5720576 | 0.77 | MEN1 (0.52) | ALDH1A1CYP3A4TDP1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7858794-B2 | Tetrahydroquinoline derivatives | N.V. ORGANON (NL) | 2010-12-28 | — | — | US | disclosed |
| US-20100022467-A1 | ANTI-CANCER PHOSPHONATE ANALOGS | BOOJAMRA CONSTANTINE G | 2010-01-28 | — | — | US | disclosed |
| US-7452901-B2 | Anti-cancer phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2008-11-18 | — | — | US | disclosed |
| US-7442698-B2 | Substituted heterocyclic compounds and methods of use | AMGEN INC. (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1218360-B1 | TRIAZINE KINASE INHIBITORS | AMGEN INC (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2003037831-A2 | METHOD FOR PREPARING 4-NITROSO-SUBSTITUTED AROMATIC AMINE | KOREA KUMHO PETROCHEMICAL CO., LTD. (KR) | 2003-05-08 | — | — | WO | disclosed |
| US-6552229-B1 | Contacting an amide with a nitroaromatic compound under basic conditions; single step; high selectivity and yield; 4-nitro-substituted aromatic amine by product | KOREA KUMHO PETROCHEMICAL CO., LTD. (KR) | 2003-04-22 | — | — | US | disclosed |
| US-4257828-A | COATINGS HAVING GOOD CORROSION RESISTANCE AND GOOD ADHESION WITH PAINTS | NIPPON PAINT CO., LTD. (JP) | 1981-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022467-A1 | ANTI-CANCER PHOSPHONATE ANALOGS | PIK3CA, PHOSPHO1, PTEN | ALDH1A1 3678/4885CYP3A4 4404/4885TDP1 1340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.