Ethane

Ethane

SCHEMBL7066097

CC.[Cl-].[Cl-].c1ccc([Zr+2]C2c3ccccc3-c3ccccc32)cc1

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Ethane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE known ✓ P22303 2/20 0.32
CHRM2 known ✓ P08172 1/20 0.32
CHRM1 known ✓ P11229 1/20 0.32
SLC6A2 known ✓ P23975 1/20 0.32
SLC6A3 known ✓ Q01959 1/20 0.32
GPR3 P46089 2/20 0.39
POLB P06746 2/20 0.37
KMT2A Q03164 2/20 0.35
MEN1 O00255 1/20 0.35
ATM Q13315 1/20 0.35
HTR2A P28223 1/20 0.34
CYP1A2 P05177 1/20 0.33
TSHR P16473 1/20 0.33
HTR1A P08908 1/20 0.32
ADRA2A P08913 1/20 0.32
DRD1 P21728 1/20 0.32
SLC6A4 P31645 1/20 0.32
ADRA1A P35348 1/20 0.32
OPRM1 P35372 1/20 0.32
DRD3 P35462 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6230981 0.86 HTR2A (0.40) GPR3POLBKMT2AMEN1ATM
Ethane SCHEMBL8163438 0.78 GPR3 (0.44) GPR3POLBKMT2AMEN1ATM
Hydrochloric Acid SCHEMBL618216 0.72 GPR3 (0.42) GPR3POLBKMT2AMEN1ATM
Hydrochloric Acid SCHEMBL8599251 0.70 GPR3 (0.41) GPR3POLBKMT2AMEN1ATM
Hydrochloric Acid SCHEMBL8378993 0.70 GPR3 (0.41) GPR3POLBKMT2AMEN1ATM
Hydrochloric Acid SCHEMBL7643268 0.70 GPR3 (0.41) GPR3POLBKMT2AMEN1ATM
SCHEMBL8702175 0.69 GPR3 (0.44) GPR3POLBKMT2AMEN1ATM
Ethylene SCHEMBL6914332 0.69 GPR3 (0.39) GPR3POLBKMT2AMEN1ATM
Hydrochloric Acid SCHEMBL524858 0.68 GPR3 (0.33) GPR3
SCHEMBL8379078 0.67 GPR3 (0.42) GPR3POLBKMT2AMEN1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1313747-A1 METHOD FOR PRODUCING ALKYL-BRIDGED LIGAND SYSTEMS AND TRANSITION METAL COMPOUNDS Basell Polypropylen GmbH (DE) 2003-05-28 EP disclosed
WO-2002018397-A1 METHOD FOR PRODUCING ALKYL-BRIDGED LIGAND SYSTEMS AND TRANSITION METAL COMPOUNDS BASELL POLYPROPYLEN GMBH (DE) 2002-03-07 WO disclosed