Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.56 |
| ▸ | BID | P55957 | 1/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CCR2 | P41597 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.52 |
| ▸ | NOD2 | Q9HC29 | 4/20 | 0.48 |
| ▸ | NOD1 | Q9Y239 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7065121 | 0.87 | HDAC1 (0.52) | BCL2BIDMCL1ALDH1A1LMNA | |
| SCHEMBL7061634 | 0.87 | CCR2 (0.55) | BCL2BIDMCL1ALDH1A1LMNA | |
| SCHEMBL7066844 | 0.83 | MCL1 (0.63) | BCL2BIDMCL1ALDH1A1LMNA | |
| SCHEMBL8716050 | 0.81 | NOD2 (0.49) | BCL2BIDMCL1ALDH1A1LMNA | |
| SCHEMBL6172779 | 0.79 | HDAC3 (0.65) | BCL2BIDMCL1ALDH1A1LMNA | |
| SCHEMBL8715760 | 0.79 | ALDH1A1 (0.52) | BCL2BIDMCL1ALDH1A1LMNA | |
| SCHEMBL7067339 | 0.79 | BCL2 (0.55) | BCL2BIDMCL1ALDH1A1LMNA | |
| SCHEMBL7067783 | 0.79 | HDAC3 (0.57) | ALDH1A1LMNAMAPTCCR2HDAC8 | |
| SCHEMBL7066597 | 0.78 | ALDH1A1 (0.52) | BCL2BIDMCL1ALDH1A1LMNA | |
| SCHEMBL7066194 | 0.78 | HDAC3 (0.53) | BCL2BIDMCL1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030158216-A1 | 2-acyl indole derivatives and their use as antitumor agents | BAXTER ONCOLOGY GMBH | 2003-08-21 | — | — | US | disclosed |
| US-20020091124-A1 | 2-acyl indole derivatives and their use as antitumor agents | BECKERS THOMAS (DE) | 2002-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030158216-A1 | 2-acyl indole derivatives and their use as antitumor agents | IDO1, IDO2, INMT | BCL2 262/4885BID 55/4885MCL1 11/4885 |
| US-20020091124-A1 | 2-acyl indole derivatives and their use as antitumor agents | IDO1, IDO2, INMT | BCL2 262/4885BID 55/4885MCL1 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.