Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.53 |
| ▸ | CCR2 | P41597 | 5/20 | 0.45 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.43 |
| ▸ | PGR | P06401 | 2/20 | 0.43 |
| ▸ | AR | P10275 | 2/20 | 0.43 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.40 |
| ▸ | ITGAL | P20701 | 2/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7063649 | 0.79 | PTGS1 (0.48) | PTGS2PTGS1CCR2ITGB2ICAM1 | |
| SCHEMBL6598563 | 0.75 | PTGS1 (0.58) | PTGS2PTGS1CCR2ITGB2ICAM1 | |
| SCHEMBL4575696 | 0.73 | PTGS1 (0.56) | PTGS2PTGS1CCR2ITGB2ICAM1 | |
| SCHEMBL14906059 | 0.72 | MCL1 (0.61) | PTGS2PTGS1CCR2MAPT | |
| SCHEMBL9538398 | 0.72 | PTGS1 (0.55) | PTGS2PTGS1CCR2ITGB2ICAM1 | |
| SCHEMBL8100630 | 0.71 | CA2 (0.44) | PTGS2PTGS1 | |
| SCHEMBL7979738 | 0.71 | PTGS2 (0.56) | PTGS2PTGS1CCR2ITGB2ICAM1 | |
| SCHEMBL9539406 | 0.71 | PTGS1 (0.54) | PTGS2PTGS1CCR2ITGB2ICAM1 | |
| SCHEMBL8481379 | 0.71 | PTGS1 (0.43) | PTGS2PTGS1CCR2ITGB2ICAM1 | |
| SCHEMBL11560825 | 0.71 | MCL1 (0.59) | PTGS2PTGS1CCR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968180-B1 | SUBSTITUTED DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLOOXYGENASE II | NYCOMED AUSTRIA GMBH (AT) | 2003-06-04 | — | — | EP | disclosed |
| US-6297282-B1 | TREATING INFLAMMATION AND PAIN | NYCOMED AUSTRIA GMBH (AT) | 2001-10-02 | — | — | US | disclosed |