Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | ITGB2 | P05107 | 5/20 | 0.37 |
| ▸ | ICAM1 | P05362 | 5/20 | 0.37 |
| ▸ | ITGAL | P20701 | 5/20 | 0.37 |
| ▸ | PTGES2 | Q9H7Z7 | 11/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7067324 | 0.82 | CA2 (0.41) | PTGS1PTGS2ITGB2ICAM1ITGAL | |
| SCHEMBL7979738 | 0.74 | PTGS2 (0.56) | PTGS1PTGS2ITGB2ICAM1ITGAL | |
| SCHEMBL7067226 | 0.72 | PTGS1 (0.53) | PTGS1PTGS2ITGB2ICAM1ITGAL | |
| SCHEMBL7067165 | 0.71 | PTGS1 (0.53) | PTGS1PTGS2PTGES2MEN1ALDH1A1 | |
| SCHEMBL7132230 | 0.68 | ITGB2 (0.40) | PTGS1PTGS2ITGB2ICAM1ITGAL | |
| SCHEMBL4575696 | 0.66 | PTGS1 (0.56) | PTGS1PTGS2ITGB2ICAM1ITGAL | |
| SCHEMBL8107827 | 0.64 | CA2 (0.48) | PTGS1PTGS2ITGB2ICAM1ITGAL | |
| SCHEMBL7063649 | 0.64 | PTGS1 (0.48) | PTGS1PTGS2ITGB2ICAM1ITGAL | |
| SCHEMBL8098906 | 0.64 | PTGS1 (0.43) | PTGS1PTGS2ITGB2ICAM1ITGAL | |
| SCHEMBL8099469 | 0.64 | CA2 (0.63) | PTGS1PTGS2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968180-B1 | SUBSTITUTED DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLOOXYGENASE II | NYCOMED AUSTRIA GMBH (AT) | 2003-06-04 | — | — | EP | disclosed |
| US-6297282-B1 | TREATING INFLAMMATION AND PAIN | NYCOMED AUSTRIA GMBH (AT) | 2001-10-02 | — | — | US | disclosed |
| EP-0968180-A1 | SUBSTITUTED DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLOOXYGENASE II | Nycomed Austria GmbH (AT) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998033769-A1 | SUBSTITUTED DERIVATIVES OF BENZOSULPHONAMIDES AS INHIBITORS OF THE ENZYME CYCLOOXYGENASE II | NYCOMED AUSTRIA GMBH (AT) | 1998-08-06 | — | — | WO | disclosed |