Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 8/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7069861 | 0.87 | POLB (0.42) | EPHX2CYP2D6CYP2C9CYP2C19KMT2A | |
| SCHEMBL7068109 | 0.74 | EPHX2 (0.47) | EPHX2CYP2D6CYP2C9CYP2C19KMT2A | |
| SCHEMBL7068112 | 0.74 | EPHX2 (0.47) | EPHX2CYP2D6CYP2C9CYP2C19KMT2A | |
| SCHEMBL7982631 | 0.71 | EPHX2 (0.48) | EPHX2CYP2D6CYP2C9CYP2C19KMT2A | |
| SCHEMBL7067645 | 0.69 | CTSG (0.56) | SMN1; SMN2 | |
| SCHEMBL7067649 | 0.69 | CTSG (0.56) | SMN1; SMN2 | |
| SCHEMBL7982892 | 0.68 | ACE (0.52) | CYP2D6CYP2C9CYP2C19KMT2AMMP1 | |
| SCHEMBL7982890 | 0.68 | ACE (0.52) | CYP2D6CYP2C9CYP2C19KMT2AMMP1 | |
| SCHEMBL7068105 | 0.68 | EPHX2 (0.47) | EPHX2CNR1KDM4ANPC1RAB9A | |
| SCHEMBL7067053 | 0.67 | CNR1 (0.42) | EPHX2CYP2D6CYP2C9CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1060161-B1 | MATRIX METALLOPROTEINASE INHIBITORS | LEO PHARMA AS WITH SECONDARY N (DK) | 2003-06-11 | — | — | EP | claimed |
| US-6277876-B1 | Matrix metalloproteinase inhibitors | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2001-08-21 | — | — | US | claimed |
| EP-1060161-B1 | MATRIX METALLOPROTEINASE INHIBITORS | LEO PHARMA AS WITH SECONDARY N (DK) | 2003-06-11 | — | — | EP | disclosed |