Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.52 |
| ▸ | MMP9 | P14780 | 6/20 | 0.52 |
| ▸ | MMP2 | P08253 | 5/20 | 0.52 |
| ▸ | MMP7 | P09237 | 3/20 | 0.52 |
| ▸ | MMP12 | P39900 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
| ▸ | MMP1 | P03956 | 4/20 | 0.48 |
| ▸ | FCER2 | P06734 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 6/20 | 0.47 |
| ▸ | MMP3 | P08254 | 2/20 | 0.47 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.46 |
| ▸ | MME | P08473 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982892 | 1.00 | ACE (0.52) | ACEMMP9MMP2MMP7MMP12 | |
| SCHEMBL7068112 | 0.91 | EPHX2 (0.47) | ACEMMP9MMP2MMP7MMP12 | |
| SCHEMBL7068109 | 0.91 | EPHX2 (0.47) | ACEMMP9MMP2MMP7MMP12 | |
| SCHEMBL27522992 | 0.88 | MMP1 (0.49) | MMP9MMP2MMP7MMP1FCER2 | |
| SCHEMBL7982632 | 0.88 | MMP1 (0.49) | MMP9MMP2MMP7MMP1FCER2 | |
| SCHEMBL27550386 | 0.88 | MMP1 (0.46) | MMP9MMP2MMP7MMP1KMT2A | |
| SCHEMBL7983199 | 0.85 | MMP1 (0.58) | ACEMMP9MMP2MMP7MMP12 | |
| SCHEMBL7983204 | 0.85 | MMP1 (0.58) | ACEMMP9MMP2MMP7MMP12 | |
| SCHEMBL7982631 | 0.82 | EPHX2 (0.48) | ACEKMT2AALDH1A1HPGDMME | |
| SCHEMBL7067645 | 0.79 | CTSG (0.56) | HPGDMMP8MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6277876-B1 | Matrix metalloproteinase inhibitors | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (DK) | 2001-08-21 | — | — | US | disclosed |
| CN-1289323-A | Matrix metalloproteinase inhibitors | LEO PHARMACEUTICAL PRODUOTS LT (DK) | 2001-03-28 | — | — | CN | disclosed |