Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.54 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.54 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.54 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.54 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.50 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.50 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7077182 | 0.86 | HSD11B1 (0.61) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL7126859 | 0.84 | ALDH1A1 (0.62) | MEN1KMT2ALMNATSHRSMN1; SMN2 | |
| SCHEMBL7074604 | 0.83 | SMN1; SMN2 (0.76) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL7074514 | 0.82 | TP53 (0.53) | MEN1KMT2ALMNASMN1; SMN2TP53 | |
| SCHEMBL7074794 | 0.82 | MEN1 (0.57) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| Acetic Acid SCHEMBL27525154 | 0.81 | ALDH1A1 (0.59) | MEN1KMT2ALMNATSHRSMN1; SMN2 | |
| SCHEMBL7072180 | 0.81 | ITGB3 (0.56) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL7071453 | 0.80 | F10 (0.58) | F2PRSS1PRSS2PRSS3TMPRSS6 | |
| SCHEMBL7387792 | 0.79 | F10 (0.46) | F2PRSS1PRSS2PRSS3MEN1 | |
| Acetic Acid SCHEMBL27530353 | 0.79 | MEN1 (0.53) | MEN1KMT2ALMNASMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |
| EP-1025086-A1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GmbH (DE) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999016751-A1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 1999-04-08 | — | — | WO | disclosed |