Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.76 |
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | TSHR | P16473 | 2/20 | 0.76 |
| ▸ | PKM | P14618 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | PKLR | P30613 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7074321 | 0.84 | CA12 (0.65) | SMN1; SMN2LMNAPKMALDH1A1MAPT | |
| SCHEMBL7077182 | 0.84 | HSD11B1 (0.61) | SMN1; SMN2LMNATSHRHSD11B1MAPT | |
| SCHEMBL7069367 | 0.83 | F2 (0.54) | SMN1; SMN2LMNATSHRPKMALDH1A1 | |
| SCHEMBL7075843 | 0.82 | ALDH1A1 (0.71) | SMN1; SMN2LMNATSHRPKMALDH1A1 | |
| Acetic Acid SCHEMBL27525158 | 0.81 | CA12 (0.61) | SMN1; SMN2LMNAPKMALDH1A1MAPT | |
| SCHEMBL7072180 | 0.81 | ITGB3 (0.56) | SMN1; SMN2LMNATSHRALDH1A1HSD11B1 | |
| SCHEMBL2952941 | 0.80 | PKM (1.00) | SMN1; SMN2LMNATSHRPKMALDH1A1 | |
| SCHEMBL7071453 | 0.80 | F10 (0.58) | SMN1; SMN2LMNATSHRPKMHTT | |
| SCHEMBL7074794 | 0.80 | MEN1 (0.57) | SMN1; SMN2LMNATSHRPKMALDH1A1 | |
| Acetic Acid SCHEMBL27525165 | 0.79 | LMNA (0.67) | SMN1; SMN2LMNATSHRPKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |
| EP-1025086-A1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GmbH (DE) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999016751-A1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 1999-04-08 | — | — | WO | disclosed |