Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.34 |
| ▸ | TPSD1 | Q9BZJ3 | 3/20 | 0.34 |
| ▸ | TPSG1 | Q9NRR2 | 3/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.33 |
| ▸ | ACSS2 | Q9NR19 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7071924 | 1.00 | NPC1 (0.34) | NPC1RAB9ATPSAB1TPSD1TPSG1 | |
| SCHEMBL7068661 | 0.93 | NPC1 (0.33) | NPC1RAB9ATPSAB1TPSD1TPSG1 | |
| SCHEMBL7068662 | 0.93 | NPC1 (0.33) | NPC1RAB9ATPSAB1TPSD1TPSG1 | |
| SCHEMBL7068659 | 0.92 | NPC1 (0.36) | NPC1RAB9ATPSAB1TPSD1TPSG1 | |
| SCHEMBL7068430 | 0.90 | NPC1 (0.35) | NPC1RAB9ATPSAB1TPSD1TPSG1 | |
| SCHEMBL7071905 | 0.85 | TPSAB1 (0.33) | NPC1RAB9ATPSAB1TPSD1TPSG1 | |
| SCHEMBL7068673 | 0.85 | ACSS2 (0.38) | NPC1RAB9AACSS2PDE4APDE4B | |
| SCHEMBL7073141 | 0.84 | MAP3K5 (0.34) | NPC1RAB9ATPSAB1TPSD1TPSG1 | |
| SCHEMBL7070129 | 0.83 | ACSS2 (0.33) | NPC1RAB9AACSS2 | |
| SCHEMBL7397634 | 0.82 | L3MBTL1 (0.41) | NPC1TPSAB1TPSD1TPSG1ACSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030212120-A1 | Compositions comprising a substituted benzimidazole useful for treating immunomediated inflammatory disorders | AXYS PHARMACEUTICALS, INC. (US) | 2003-11-13 | — | — | US | disclosed |
| US-6562854-B2 | Antiinflammatory agents; respiratory system disorders | AXYS PHARMACEUTICALS, INC. | 2003-05-13 | — | — | US | disclosed |
| US-20010053779-A1 | Novel compounds and compositions for treating diseases asociated with protease activity | Celera Corporation | 2001-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010053779-A1 | Novel compounds and compositions for treating diseases asociated with protease activity | CMA1, CPA3, TPSG1 | NPC1 1362/4885RAB9A 791/4885TPSAB1 5/4885 |
| US-20030212120-A1 | Compositions comprising a substituted benzimidazole useful for treating immunomediated inflammatory disorders | CMA1, TPSG1, TPSD1 | NPC1 3932/4885RAB9A 1714/4885TPSAB1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.