Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.40 |
| ▸ | LATS1 | O95835 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | MYC | P01106 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6942143 | 0.68 | CYP2A6 (0.37) | — | |
| SCHEMBL7077154 | 0.67 | HTR6 (0.41) | PRMT5WDR77IDO1 | |
| SCHEMBL7075974 | 0.67 | CCR1 (0.47) | — | |
| SCHEMBL14320606 | 0.64 | APP (0.50) | IMPDH2CHEK1CHEK2PRMT5WDR77 | |
| SCHEMBL7070801 | 0.64 | ADORA2A (0.44) | — | |
| SCHEMBL8009682 | 0.63 | METAP2 (0.44) | — | |
| SCHEMBL6129041 | 0.62 | NPC1 (0.46) | IMPDH2CHEK1CHEK2MYC | |
| SCHEMBL13822164 | 0.62 | ASIC3 (0.47) | IMPDH2MYCIDO1 | |
| SCHEMBL7071995 | 0.61 | KDM4E (0.37) | — | |
| SCHEMBL571374 | 0.61 | HDAC8 (0.50) | IMPDH2CHEK1CHEK2PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349857-A1 | PURINE DERIVATIVES AS PURINERGIC RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002055521-A1 | PURINE DERIVATIVES AS PURINERGIC RECEPTOR ANTAGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2002-07-18 | — | — | WO | disclosed |