Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5127363 | 0.72 | SIGMAR1 (0.43) | RAB9AKDM4EKEAP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5131192 | 0.69 | RAB9A (0.48) | RAB9AKDM4EKEAP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL17393052 | 0.69 | ALDH1A1 (0.43) | KDM4EKEAP1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL2595940 | 0.68 | KDM4E (0.46) | RAB9AKDM4EKEAP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL15515230 | 0.67 | KEAP1 (0.42) | KDM4EKEAP1SMN1; SMN2ALDH1A1GLA | |
| SCHEMBL3191016 | 0.67 | RAB9A (0.35) | RAB9AKDM4EKEAP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL11050940 | 0.67 | KMT2A (0.33) | RAB9AALDH1A1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL11687169 | 0.66 | GLA (0.45) | RAB9AKDM4EKEAP1SMN1; SMN2ALDH1A1 | |
| Bromide SCHEMBL28242666 | 0.66 | KDM4E (0.45) | RAB9AKDM4EKEAP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL235080 | 0.66 | KDM4E (0.65) | KDM4EKEAP1SMN1; SMN2ALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259599-A4 | CELL FUSION ASSAYS USING FLUORESCENCE RESONANCE ENERGY TRANSFER | MERCK & CO INC (US) | 2003-08-20 | — | — | EP | disclosed |
| EP-1297341-A2 | METHODS OF IDENTIFYING GABA B? RECEPTOR SUBTYPE-SPECIFIC AGONISTS | MERCK FROSST CANADA INC. (CA) | 2003-04-02 | — | — | EP | disclosed |
| EP-1259599-A1 | CELL FUSION ASSAYS USING FLUORESCENCE RESONANCE ENERGY TRANSFER | Merck & Co., Inc. (US) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001098779-A2 | METHODS OF IDENTIFYING GABAB RECEPTOR SUBTYPE-SPECIFIC AGONISTS | MERCK FROSST CANADA & CO. (CA) | 2001-12-27 | — | — | WO | disclosed |
| WO-2001060995-A1 | CELL FUSION ASSAYS USING FLUORESCENCE RESONANCE ENERGY TRANSFER | MERCK & CO., INC. (US) | 2001-08-23 | — | — | WO | disclosed |