Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR17 | Q13304 | 3/20 | 0.61 |
| ▸ | BCL2 | P10415 | 2/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | CCR2 | P41597 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842628 | 0.80 | KDM4E (0.47) | BCL2MCL1KDM4EALDH1A1HPGD | |
| SCHEMBL7592453 | 0.76 | GPR35 (0.43) | GPR17CYP2C9CYP2C19GAANPSR1 | |
| SCHEMBL9186531 | 0.76 | GPR17 (1.00) | GPR17KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL3659426 | 0.75 | KDM4E (0.60) | GPR17KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1144751 | 0.73 | GPR17 (0.64) | GPR17KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7680945 | 0.72 | PTPRC (0.44) | GPR17ALDH1A1HPGDMAPT | |
| SCHEMBL7682574 | 0.72 | KDM4A (0.43) | GPR17ALDH1A1KMT2AMEN1CCR2 | |
| SCHEMBL7076761 | 0.72 | MCL1 (0.48) | GPR17BCL2MCL1KDM4EKMT2A | |
| SCHEMBL30779683 | 0.72 | GPR17 (0.63) | GPR17KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7074236 | 0.70 | POLB (0.47) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003504-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-07-02 | — | — | EP | disclosed |