Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.43 |
| ▸ | GPR17 | Q13304 | 3/20 | 0.41 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.41 |
| ▸ | PRNP | P04156 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7072708 | 0.76 | GPR17 (0.61) | GPR17CYP2C9CYP2C19NPSR1GAA | |
| SCHEMBL7842628 | 0.74 | KDM4E (0.47) | PRNPCYP1A2CYP2C9CYP2C19PPARG | |
| SCHEMBL7074236 | 0.73 | POLB (0.47) | CNR1 | |
| SCHEMBL7680945 | 0.73 | PTPRC (0.44) | GPR17RNASEH1 | |
| SCHEMBL7682574 | 0.73 | KDM4A (0.43) | GPR17RNASEH1 | |
| SCHEMBL27566482 | 0.73 | GPR35 (0.39) | GPR35GPR17 | |
| Ethyne SCHEMBL7605585 | 0.72 | GPR17 (0.45) | GPR17RNASEH1 | |
| SCHEMBL7074182 | 0.72 | EGFR (0.50) | NPSR1CNR1 | |
| SCHEMBL7076761 | 0.71 | MCL1 (0.48) | GPR17RNASEH1GAA | |
| SCHEMBL8095087 | 0.68 | RNASEH1 (0.42) | GPR17RNASEH1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252142-A1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001051466-A1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2001-07-19 | — | — | WO | disclosed |