Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.45 |
| ▸ | BCL2 | P10415 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.43 |
| ▸ | PRNP | P04156 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7072708 | 0.80 | GPR17 (0.61) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL7074236 | 0.75 | POLB (0.47) | POLBCNR1 | |
| SCHEMBL7592453 | 0.74 | GPR35 (0.43) | CNR1PRNPCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7074182 | 0.74 | EGFR (0.50) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL7682574 | 0.71 | KDM4A (0.43) | ALDH1A1 | |
| SCHEMBL7680945 | 0.71 | PTPRC (0.44) | ALDH1A1HPGDABCB11MAPT | |
| SCHEMBL7076761 | 0.70 | MCL1 (0.48) | KDM4EMCL1BCL2MAPT | |
| SCHEMBL27846878 | 0.69 | KDM4E (0.49) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| SCHEMBL473532 | 0.69 | LMNA (0.52) | KDM4EALDH1A1ABCB11POLBMAPT | |
| SCHEMBL8938387 | 0.69 | NHERF1 (0.66) | KDM4EALDH1A1POLBCNR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150952-A1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046196-A1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |