Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 8/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | KIF11 | P52732 | 3/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7074182 | 0.92 | EGFR (0.50) | POLBPKMCNR1KIF11ENPP2 | |
| SCHEMBL7842628 | 0.75 | KDM4E (0.47) | POLBCNR1 | |
| SCHEMBL7592453 | 0.73 | GPR35 (0.43) | CNR1 | |
| SCHEMBL7072708 | 0.70 | GPR17 (0.61) | POLB | |
| SCHEMBL7682574 | 0.70 | KDM4A (0.43) | — | |
| SCHEMBL8095087 | 0.70 | RNASEH1 (0.42) | POLB | |
| SCHEMBL7680945 | 0.70 | PTPRC (0.44) | — | |
| SCHEMBL17373719 | 0.70 | CNR1 (0.79) | CNR1CNR2EGFRCDK2PTGS2 | |
| SCHEMBL8938387 | 0.68 | NHERF1 (0.66) | POLBPKMCNR1 | |
| SCHEMBL7076761 | 0.68 | MCL1 (0.48) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003504-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-07-02 | — | — | EP | disclosed |