Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.42 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 3/20 | 0.38 |
| ▸ | GPR17 | Q13304 | 2/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | PTGFR | P43088 | 1/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.36 |
| ▸ | PTGIR | P43119 | 1/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.36 |
| ▸ | PTPRG | P23470 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7678604 | 0.83 | PTGES (0.47) | MEN1ALDH1A1KMT2A | |
| SCHEMBL7680945 | 0.77 | PTPRC (0.44) | KDM4AKDM5AKDM5BRNASEH1HAO1 | |
| SCHEMBL7076761 | 0.74 | MCL1 (0.48) | KDM4AKDM5AKDM5BRNASEH1MEN1 | |
| SCHEMBL7072708 | 0.72 | GPR17 (0.61) | MEN1ALDH1A1KMT2ACCR2GPR17 | |
| SCHEMBL8095087 | 0.72 | RNASEH1 (0.42) | KDM4AKDM5AKDM5BRNASEH1HAO1 | |
| SCHEMBL7074182 | 0.71 | EGFR (0.50) | MEN1ALDH1A1KMT2A | |
| SCHEMBL7074236 | 0.70 | POLB (0.47) | — | |
| Ethyne SCHEMBL7605585 | 0.68 | GPR17 (0.45) | KDM4AKDM5AKDM5BRNASEH1GPR17 | |
| SCHEMBL8093064 | 0.68 | PTK2 (0.47) | KDM4AKDM5AKDM5BRNASEH1HAO1 | |
| SCHEMBL27873446 | 0.67 | PTPRG (0.56) | KDM4AKDM5AKDM5BRNASEH1HAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479527-B1 | Bicyclic pyrrole derivatives as MCP-1 inhibitors | ASTRAZENECA UK LIMITED (GB) | 2002-11-12 | — | — | US | disclosed |
| EP-1056451-A1 | BICYCLIC PYRROLE DERIVATIVES AS MCP-1 INHIBITORS | AstraZeneca UK Limited (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999040914-A1 | BICYCLIC PYRROLE DERIVATIVES AS MCP-1 INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |