Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 15/20 | 0.61 |
| ▸ | THRA | P10827 | 14/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TPMT | P51580 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7220499 | 0.90 | THRB (0.69) | THRBTHRAPPARGHSD17B10ALOX15 | |
| SCHEMBL287411 | 0.89 | THRB (0.49) | THRBTHRAPPARGTSHR | |
| SCHEMBL7952084 | 0.84 | THRA (0.58) | THRBTHRAHSD17B10ALOX15TSHR | |
| SCHEMBL11157934 | 0.81 | GAA (0.54) | THRBHSD17B10ALOX15TSHR | |
| SCHEMBL19679636 | 0.80 | THRB (0.53) | THRBTHRAPPARGHSD17B10TSHR | |
| SCHEMBL1302320 | 0.80 | THRB (0.56) | THRBTHRAPPARGHSD17B10ALOX15 | |
| SCHEMBL7796619 | 0.78 | NR1H4 (0.45) | THRBTHRAPPARGTSHR | |
| SCHEMBL15026095 | 0.77 | THRB (0.53) | THRBTHRAPPARGHSD17B10TSHR | |
| SCHEMBL5859452 | 0.76 | THRB (0.62) | THRBTHRAPPARG | |
| SCHEMBL28033890 | 0.76 | THRB (0.50) | THRBTHRAPPARGHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000008-B1 | NOVEL THYROID RECEPTOR LIGANDS AND METHOD | KAROBIO AB (SE) | 2003-06-25 | — | — | EP | disclosed |
| US-6465687-B1 | SUBSTITUTED 4-HYDROXY-3-ALKYL- OR CYCLOALKYL-PHENOXYBENZENE COMPOUNDS SUCH AS 3,5-DIBROMO-4-(4-HYDROXY-3-ISOPROPYLPHENOXY)BENZOIC ACID, EXPRESSION INHIBITION OF A T3 REGULATED GENE | KARO BIO AB (SE) | 2002-10-15 | — | — | US | disclosed |
| EP-1000008-A1 | NOVEL THYROID RECEPTOR LIGANDS AND METHOD | KARO BIO AB (SE) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999000353-A1 | NOVEL THYROID RECEPTOR LIGANDS AND METHOD | KARO BIO AB (SE) | 1999-01-07 | — | — | WO | disclosed |