Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 17/20 | 0.58 |
| ▸ | THRB | P10828 | 17/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3669296 | 0.90 | NPSR1 (0.52) | THRATHRBFFAR4 | |
| SCHEMBL7073649 | 0.84 | THRB (0.61) | THRATHRBNR3C1ALOX15TSHR | |
| SCHEMBL7953719 | 0.84 | ALDH1A1 (0.48) | THRATHRB | |
| SCHEMBL7792155 | 0.79 | FFAR1 (0.44) | THRATHRBFFAR4 | |
| SCHEMBL3683664 | 0.79 | THRA (0.50) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL10750673 | 0.78 | NPC1 (0.50) | THRATHRBNR3C1NR3C2FFAR4 | |
| SCHEMBL27846789 | 0.78 | NPSR1 (0.53) | THRATHRBFFAR4 | |
| SCHEMBL5859480 | 0.78 | THRA (0.64) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL4899318 | 0.77 | THRB (0.71) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL14553370 | 0.76 | FFAR1 (0.55) | THRATHRBFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235789-B1 | GLANDULAR DISORDERS; SLEEP DISORDERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0781271-B1 | BENZOCYCLOALKENE COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-06-07 | — | — | EP | disclosed |
| EP-0781271-A1 | BENZOCYCLOALKENE COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1997-07-02 | — | — | EP | disclosed |
| WO-1996008466-A1 | BENZOCYCLOALKENE COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-21 | — | — | WO | disclosed |