Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 9/20 | 0.45 |
| ▸ | THRB | P10828 | 6/20 | 0.45 |
| ▸ | THRA | P10827 | 2/20 | 0.44 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7069931 | 0.80 | THRA (0.53) | THRBTHRA | |
| SCHEMBL7050847 | 0.77 | THRB (0.54) | RORCTHRBTHRA | |
| SCHEMBL8047083 | 0.75 | THRB (0.47) | RORCTHRBTHRALPAR1 | |
| SCHEMBL31614252 | 0.73 | ALDH1A1 (0.47) | — | |
| SCHEMBL7069500 | 0.72 | FOLH1 (0.50) | — | |
| SCHEMBL5351651 | 0.72 | THRB (0.53) | RORCTHRBTHRA | |
| SCHEMBL5363051 | 0.71 | THRB (0.58) | RORCTHRBTHRA | |
| SCHEMBL7073270 | 0.71 | RORC (0.52) | RORCTHRBTHRA | |
| SCHEMBL5355833 | 0.71 | THRB (0.55) | RORCTHRBTHRA | |
| SCHEMBL8064359 | 0.70 | RORC (0.43) | RORCTHRBTHRALPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000008-B1 | NOVEL THYROID RECEPTOR LIGANDS AND METHOD | KAROBIO AB (SE) | 2003-06-25 | — | — | EP | disclosed |
| US-6465687-B1 | SUBSTITUTED 4-HYDROXY-3-ALKYL- OR CYCLOALKYL-PHENOXYBENZENE COMPOUNDS SUCH AS 3,5-DIBROMO-4-(4-HYDROXY-3-ISOPROPYLPHENOXY)BENZOIC ACID, EXPRESSION INHIBITION OF A T3 REGULATED GENE | KARO BIO AB (SE) | 2002-10-15 | — | — | US | disclosed |