SCHEMBL7075563

SCHEMBL7075563

CC(O)C(=O)Nc1c(I)c(C(N)=O)c(I)c(C(=O)N(C(CO)CO)C(CO)CO)c1I

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.55
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28451566 1.00 LMNA (0.55) LMNASMN1; SMN2
SCHEMBL29084760 0.92 LMNA (0.47) LMNA
SCHEMBL28309840 0.85 LMNA (0.63) LMNASMN1; SMN2
SCHEMBL7046446 0.85 LMNA (0.63) LMNASMN1; SMN2
SCHEMBL7076147 0.84 LMNA (0.39) LMNA
SCHEMBL8622218 0.82 LMNA (0.50) LMNA
SCHEMBL9171058 0.82 LMNA (0.53) LMNASMN1; SMN2
SCHEMBL28551111 0.82 LMNA (0.35) LMNA
SCHEMBL29084754 0.80 LMNA (0.39) LMNA
SCHEMBL7709204 0.78 LMNA (0.90) LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117164476-A Iopanol amorphous material and preparation method thereof 江苏宇田医药有限公司 2023-12-05 CN disclosed
CN-100336800-C Preparation method of S-N, N' -bis [ 2-hydroxy-1- (hydroxymethyl) ethyl ] -5- [ (2-hydroxy-1-oxopropyl) amino ] -2, 4, 6-triiodo-1, 3-benzenedicarboxamide DIBRA SPA (IT) 2007-09-12 CN disclosed
EP-1075462-B1 PROCESS FOR THE PREPARATION OF S- N,N'- BIS[2- HYDROXY-1- (HYDROXYMETHYL) ETHYL]-5- [(2- HYDROXY-1- OXOPROPYL)- AMINO]- 2,4,6- TRIIODO- 1,3- BENZENEDICARBOXAMIDE BRACCO IMAGING SPA (IT) 2003-06-25 EP disclosed
CN-1302288-A Method for preparing S-N, N' -bis [ 2-hydroxy-1- (hydroxymethyl) ethyl ] -5- [ (2-hydroxy-1-oxopropyl) amino ] -2, 4, 6-triiodo-1, S-benzenedicarboxamide DIBRA SPA (IT) 2001-07-04 CN disclosed
EP-1075462-A2 PROCESS FOR THE PREPARATION OF S- N,N'- BIS[2- HYDROXY-1- (HYDROXYMETHYL) ETHYL]-5- [(2- HYDROXY-1- OXOPROPYL)- AMINO]- 2,4,6- TRIIODO- 1,3- BENZENEDICARBOXAMIDE BRACCO IMAGING S.p.A. (IT) 2001-02-14 EP disclosed
WO-1999058494-A3 PROCESS FOR THE PREPARATION OF S- N,N'- BIS[2- HYDROXY-1- (HYDROXYMETHYL) ETHYL]-5- [(2- HYDROXY-1- OXOPROPYL)- AMINO]- 2,4,6- TRIIODO- 1,3- BENZENEDICARBOXAMIDE BRACCO INT BV (NL) 2000-01-20 WO disclosed
WO-1999058494-A2 PROCESS FOR THE PREPARATION OF S- N,N'- BIS[2- HYDROXY-1- (HYDROXYMETHYL) ETHYL]-5- [(2- HYDROXY-1- OXOPROPYL)- AMINO]- 2,4,6- TRIIODO- 1,3- BENZENEDICARBOXAMIDE DIBRA S.P.A. (IT) 1999-11-18 WO disclosed
WO-1998034908-A1 PROCESS FOR THE CRYSTALLIZATION FROM A LINEAR OR BRANCHED (C5-C6) ALCOHOL OR THEIR MIXTURES OF (S)-N,N'-bis[2-HYDROXY-1- (HYDROXYMETHYL)ETHYL]-5-[ (2-HYDROXY-1-OXOPROPYl)AMINO]-2,4,6- TRIIODO-1,3-BENZENDICARBOXAMIDE BRACCO INTERNATIONAL B.V. (NL) 1998-08-13 WO disclosed
EP-0119020-B1 METHOD OF PREPARING LIPOSOMES AND PRODUCTS PRODUCED THEREBY E.R. Squibb & Sons, Inc. (US) 1988-06-01 EP disclosed