Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 18/20 | 0.53 |
| ▸ | MMP13 | P45452 | 18/20 | 0.53 |
| ▸ | MMP1 | P03956 | 16/20 | 0.53 |
| ▸ | ADAM17 | P78536 | 9/20 | 0.53 |
| ▸ | MMP2 | P08253 | 4/20 | 0.51 |
| ▸ | MMP8 | P22894 | 4/20 | 0.51 |
| ▸ | MMP12 | P39900 | 4/20 | 0.51 |
| ▸ | MMP14 | P50281 | 4/20 | 0.51 |
| ▸ | MMP16 | P51512 | 4/20 | 0.51 |
| ▸ | MMP3 | P08254 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7076474 | 0.88 | TP53 (0.50) | MMP9MMP13MMP1ADAM17L3MBTL1 | |
| SCHEMBL7072875 | 0.86 | L3MBTL1 (0.48) | MMP13MMP2MMP8MMP12MMP14 | |
| SCHEMBL5898955 | 0.80 | MMP9 (0.62) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7072106 | 0.79 | MMP13 (0.64) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7076508 | 0.77 | HTT (0.52) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL7076484 | 0.71 | MMP2 (0.67) | MMP9MMP13MMP1ADAM17MMP2 | |
| SCHEMBL15480646 | 0.69 | HDAC1 (0.53) | — | |
| SCHEMBL7319166 | 0.69 | MMP9 (1.00) | MMP9MMP13MMP1ADAM17MMP12 | |
| SCHEMBL7321001 | 0.69 | MMP9 (0.71) | MMP9MMP13MMP1ADAM17 | |
| SCHEMBL7073806 | 0.69 | CA1 (0.52) | MMP9MMP13MMP2MMP8MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030022893-A1 | Hydroxamic and carboxylic acid derivatives | BAXTER ANDREW DOUGLAS (GB) | 2003-01-30 | — | — | US | claimed |
| US-6465468-B1 | SUCH AS N-HYDROXY-2-(4-(4-CHLOROPHENYL)PIPERAZINE-1-SULFONYL)BENZAMIDE; INHIBITORS OF MATRIX METALLOPROTEINASE, ADAM OR ADAMTS ENZYMES; TREATMENT OF DEGENERATIVE DISEASES AND CERTAIN CANCERS | DARWIN DISCOVERY LIMITED (GB) | 2002-10-15 | — | — | US | claimed |
| US-20030022893-A1 | Hydroxamic and carboxylic acid derivatives | BAXTER ANDREW DOUGLAS (GB) | 2003-01-30 | — | — | US | disclosed |