Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7074156 | 0.88 | LMNA (0.55) | LMNAMAPTMAPK1POLBHPGD | |
| SCHEMBL7649347 | 0.87 | LMNA (0.53) | LMNAMAPTPOLBKMT2ANPSR1 | |
| SCHEMBL7071592 | 0.84 | LMNA (0.50) | LMNAMAPTPOLBHPGDHTT | |
| SCHEMBL7070051 | 0.83 | LMNA (0.52) | LMNAMAPTPOLBHPGDHTT | |
| SCHEMBL7070564 | 0.81 | LMNA (0.49) | LMNAMAPTMAPK1HTTKMT2A | |
| SCHEMBL7075110 | 0.81 | LMNA (0.49) | LMNAMAPTMAPK1POLBHPGD | |
| SCHEMBL7071584 | 0.81 | GAA (0.52) | LMNAMAPTPOLBHTTTSHR | |
| SCHEMBL7076863 | 0.80 | LSS (0.49) | LMNAMAPTMAPK1POLBTSHR | |
| SCHEMBL7070226 | 0.80 | THRB (0.54) | LMNAMAPTPOLBHTTTSHR | |
| SCHEMBL7076585 | 0.79 | TSHR (0.47) | LMNAMAPTMAPK1HTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |