Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 4/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7083692 | 0.80 | SIGMAR1 (0.39) | HDAC4CNR2P2RX7HSD11B1 | |
| SCHEMBL7080253 | 0.78 | HDAC4 (0.32) | HDAC4MEN1KMT2ACYP2D6CNR2 | |
| SCHEMBL7081986 | 0.76 | P2RX7 (0.39) | HDAC4CNR2P2RX7HSD11B1 | |
| SCHEMBL12760777 | 0.76 | MEN1 (0.35) | MEN1KMT2ACNR2EPHX2P2RX7 | |
| SCHEMBL7079060 | 0.73 | HDAC4 (0.38) | HDAC4PDK2ALDH1A1HSD11B1 | |
| SCHEMBL7082454 | 0.73 | — | — | |
| SCHEMBL4607913 | 0.72 | P2RX7 (0.40) | MEN1KMT2ACNR2EPHX2P2RX7 | |
| SCHEMBL14666300 | 0.64 | RARB (0.47) | MEN1KMT2AEPHX2P2RX7ALDH1A1 | |
| SCHEMBL677549 | 0.64 | P2RX7 (0.37) | MEN1KMT2ACNR2EPHX2P2RX7 | |
| SCHEMBL5610444 | 0.64 | P2RX7 (0.37) | MEN1KMT2AEPHX2P2RX7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003064372-A1 | 2-ADAMANTYLALKYLAMINES AND THEIR USE IN THE TREATMENT OF CONDITIONS GENERALLY ASSOCIATED WITH ABNORMALITIES IN GLUTAMATERGIC TRANSMISSION | VERNALIS RESEARCH LIMITED (GB) | 2003-08-07 | — | — | WO | disclosed |