Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7081986 | 0.80 | P2RX7 (0.39) | P2RX7HSD11B1CNR2HSD11B2HDAC4 | |
| SCHEMBL7078036 | 0.80 | HDAC4 (0.39) | P2RX7HSD11B1CNR2HDAC4 | |
| SCHEMBL12760777 | 0.76 | MEN1 (0.35) | P2RX7HSD11B1CNR2HSD11B2 | |
| SCHEMBL7079060 | 0.76 | HDAC4 (0.38) | SIGMAR1HSD11B1HDAC4 | |
| SCHEMBL1397784 | 0.75 | HSD11B1 (0.40) | SIGMAR1P2RX7GRIN2BGRIN2DGRIN3B | |
| SCHEMBL4607913 | 0.75 | P2RX7 (0.40) | P2RX7GRIN2BGRIN2DGRIN3BGRIN1 | |
| SCHEMBL7083525 | 0.75 | P2RX7 (0.33) | SIGMAR1P2RX7GRIN2BGRIN2DGRIN3B | |
| SCHEMBL9721521 | 0.74 | HSD11B1 (0.42) | SIGMAR1P2RX7GRIN2BGRIN2DGRIN3B | |
| SCHEMBL6684047 | 0.74 | SIGMAR1 (0.33) | SIGMAR1P2RX7GRIN2BGRIN2DGRIN3B | |
| SCHEMBL20693588 | 0.71 | GRIN2B (0.35) | SIGMAR1P2RX7GRIN2BGRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003064372-A1 | 2-ADAMANTYLALKYLAMINES AND THEIR USE IN THE TREATMENT OF CONDITIONS GENERALLY ASSOCIATED WITH ABNORMALITIES IN GLUTAMATERGIC TRANSMISSION | VERNALIS RESEARCH LIMITED (GB) | 2003-08-07 | — | — | WO | disclosed |