Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE6D | O43924 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 2/20 | 0.46 |
| ▸ | MPI | P34949 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28358758 | 0.89 | ALDH1A1 (0.50) | KMT2AMEN1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10869116 | 0.76 | PDE6D (0.81) | PDE6DKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL2865639 | 0.76 | KMT2A (0.42) | KMT2AMEN1ALDH1A1POLBHTT | |
| SCHEMBL28190986 | 0.76 | CES1 (0.56) | ALDH1A1GAA | |
| SCHEMBL9290287 | 0.73 | PDE6D (0.82) | PDE6DKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL30267 | 0.73 | CES1 (0.38) | KMT2AMEN1ALDH1A1POLBGAA | |
| SCHEMBL1101925 | 0.71 | KMT2A (0.62) | PDE6DKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL9290288 | 0.70 | ALDH1A1 (0.79) | PDE6DKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL9290285 | 0.70 | PDE6D (0.61) | PDE6DKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL24317276 | 0.70 | PDE6D (0.50) | PDE6DKMT2AMEN1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358180-A2 | NAPHTHOSTYRIL DERIVATIVES AND THEIR USE AS INHIBITORS OF CYCLIN-DEPENDENT KINASES | F. Hoffmann-La Roche AG (CH) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002059109-A2 | NAPHTHOSTYRIL DERIVATIVES AND THEIR USE AS INHIBITORS OF CYCLIN- DEPENDENT KINASES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-01 | — | — | WO | disclosed |